Gingival Enlargement in Patients who Have Undergone Renal Transplants: A Meta-Analysis

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dc.authoridOzveren, Neslihan/0000-0002-1090-5415
dc.contributor.authorSerindere, Gozde
dc.contributor.authorOzveren, Neslihan
dc.date.accessioned2024-09-18T20:13:43Z
dc.date.available2024-09-18T20:13:43Z
dc.date.issued2018
dc.departmentHatay Mustafa Kemal Ãœniversitesien_US
dc.description.abstractSevere gingival enlargement (GE) is one of the most commonly observed adverse effects in patients who have undergone renal transplants due to the use of cyclosporine A. Objectives: We aimed to gain more insight into the prevalence of GE in patients with renal transplants. Methods: We searched the PubMed and Web of Science databases for relevant studies from January 1990 to January 2018. Using random effects models, we calculated summary incidence rates and 95% confidence intervals (CIs). Results: A total of 595 patients from 10 studies were included. Patients using cyclosporine A with or without any other drugs had a 62.6% (95% CI, 41.9%-79.5%) incidence of GE. Subgroup analysis according to diagnostic criteria showed that the incidence of GE was lower when using well-defined diagnostic criteria or scoring system. The incidence of GE was 88.2% (95% CI, 80.9%-93.0%) in patients using cyclosporine A with nifedipine. Cyclosporine A without nifedipine was associated with a significantly decreased risk of GE incidence when compared with the combination of cyclosporine A and nifedipine (odds ratio: 0.198; 95% CI, 0.083-0.473; P < 0.001). Conclusions: It is important for all clinicians to know the effects of the aforementioned drugs and the treatment options.en_US
dc.identifier.doi10.14693/jdi.v25i2.1231
dc.identifier.endpage120en_US
dc.identifier.issn1693-9697
dc.identifier.issn2355-4800
dc.identifier.issue2en_US
dc.identifier.startpage114en_US
dc.identifier.urihttps://doi.org/10.14693/jdi.v25i2.1231
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9335
dc.identifier.volume25en_US
dc.identifier.wosWOS:000448648700008en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherUniv Indonesia, Fac Dentistryen_US
dc.relation.ispartofJournal of Dentistry Indonesiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcyclosporine Aen_US
dc.subjectgingival enlargementen_US
dc.subjectgingival overgrowthen_US
dc.subjectrenal transplantationen_US
dc.titleGingival Enlargement in Patients who Have Undergone Renal Transplants: A Meta-Analysisen_US
dc.typeArticleen_US

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