Inducible nitric oxide synthase and apoptosis in human B cell lymphomas

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dc.contributor.authorAtik, Esin
dc.contributor.authorErgin, Melek
dc.contributor.authorErdogan, Seyda
dc.contributor.authorTuncer, Ilhan
dc.date.accessioned2024-09-18T20:02:34Z
dc.date.available2024-09-18T20:02:34Z
dc.date.issued2006
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractNitric oxide synthases are isoenzymes that catalyse the synthesis of nitric oxide (NO). NO plays both pathological and physiological roles depending on its rate of synthesis and concentration in cellular source and microenvironment. Apoptosis is an important biological factor in lymphomas. This study evaluates expression of inducible nitric oxide synthase (iNOS) in human lymphomas and its relation with apoptosis. This study comprised 46 cases of B-cell lymphoma. The lymphomas were classified as 3 mantle cell, 5 marginal zone, 4 follicular, 2 Burkitt, 25 diffuse large cell, 2 anaplastic large cell, 3 lymphoblastic, 2 lymphoplasmacytic according to WHO classification of lymphoid neoplasms. Hematoxylin eosin slides of the cases were reviewed and immunoperoxidase technique was performed iNOS and Caspase monoclonal antibodies to selected sections of each case. Antigen staining was carried out with iNOS and Caspase proteins and Ultravision Polyvalent, HRP-AEC kit (Neomarkers-Biogen USA). For the evaluation of iNOS and Caspase, tumor areas with a high density of expression were chosen. Positive stained cells were counted in 5 different areas at a magnification x40 by an Olympus B x 51 microscope in each case. The iNOS and Caspase expressions were independently recorded by four pathologists and the results were averaged. All of the cases were positive for the iNOS and Caspase. But there is not a statistically important relation between lymphoma grade and iNOS activity. We could not find a correlation between iNOS and patients age. This study reveals the capacity of B-cell neoplasms to express iNOS in situ. In conclusion, our study revealed that there is a positive relation between iNOS expression and apoptosis (p = 0.032 spearman correlation).en_US
dc.identifier.doi10.1007/s11010-005-9114-2
dc.identifier.endpage209en_US
dc.identifier.issn0300-8177
dc.identifier.issue1-2en_US
dc.identifier.pmid16924421en_US
dc.identifier.scopus2-s2.0-33749169389en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage205en_US
dc.identifier.urihttps://doi.org/10.1007/s11010-005-9114-2
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7868
dc.identifier.volume290en_US
dc.identifier.wosWOS:000240802100026en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofMolecular and Cellular Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectapoptosisen_US
dc.subjectcaspaseen_US
dc.subjectiNOSen_US
dc.subjectlymphomaen_US
dc.titleInducible nitric oxide synthase and apoptosis in human B cell lymphomasen_US
dc.typeArticleen_US

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