The effect of ondansetron on analgesic efficacy of acetaminophen after hysterectomy: A randomized double blinded placebo controlled trial

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dc.contributor.authorKoyuncu, Onur
dc.contributor.authorLeung, Steve
dc.contributor.authorYou, Jing
dc.contributor.authorOksar, Menekse
dc.contributor.authorTurhanoglu, Selim
dc.contributor.authorAkkurt, Cagla
dc.contributor.authorDolapcioglu, Kenan
dc.date.accessioned2024-09-18T19:54:20Z
dc.date.available2024-09-18T19:54:20Z
dc.date.issued2017
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjectives: To determine that perioperative ondansetron reduces the analgesic efficacy of acetaminophen. Design: Randomized, double-blinded study. Patients: 120 patients ASA I-II who underwent abdominal hysterectomy. Interventions: All the patients were given 1 g acetaminophen at skin closure. Patients were divided into two groups; ondansetron HCI (8 mg, 2 ml IV) (Group I, N = 60) and saline (2 ml IV) (Group II, N = 60) at the skin closure. Measurement: Postoperative pain scores (VAS) while resting in bed and sitting, total opioid consumption were noted. Main results: Patients randomized to ondansetron had significantly worse pain scores upon arrival to the recovery unit [by 1.7 (99.7% CI: 0.75, 2.59) cm] and at 1 h [by 13 (0.5, 2.1) cm] while resting in bed. Pain scores while sitting were also significantly greater in ondansetron group at arrival in PACU by 0.6 (99.7% CI: 0.1, 1.0) cm. Thereafter, pain scores did not differ significantly. Median total opioid (tramadol) consumption was 441 [QI, Q3: 280, 578] mg in the ondansetron group and 412 [309, 574] mg in the placebo group, P = 0.95. Conclusions: Ondansetron significantly decreased the analgesic effect of acetaminophen during the initial postoperative period. Our results thus confirm that acetaminophen analgesia is partially mediated by serotonin receptors. However, the reduction was of marginal clinical importance and short-lived. (C) 2017 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipTUBITAK: Technology and Innovation Support Programs, Directorate of the Scientific and Research Council of Turkeyen_US
dc.description.sponsorshipDr. Onur Koyuncu was supported by a grant for life expenses from TUBITAK: Technology and Innovation Support Programs, Directorate of the Scientific and Research Council of Turkey. The work was presented in part at the American Society of Anesthesiologists Annual Meeting, October 12 2015, San Diego.en_US
dc.identifier.doi10.1016/j.jclinane.2017.03.049
dc.identifier.endpage83en_US
dc.identifier.issn0952-8180
dc.identifier.issn1873-4529
dc.identifier.pmid28625456en_US
dc.identifier.scopus2-s2.0-85018379884en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage78en_US
dc.identifier.urihttps://doi.org/10.1016/j.jclinane.2017.03.049
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7670
dc.identifier.volume40en_US
dc.identifier.wosWOS:000404817100021en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofJournal of Clinical Anesthesiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnesthesiaen_US
dc.subjectAcetaminophenen_US
dc.subjectAbdominal hysterectomyen_US
dc.subjectSerotonergic pathwayen_US
dc.subjectPostoperative painen_US
dc.titleThe effect of ondansetron on analgesic efficacy of acetaminophen after hysterectomy: A randomized double blinded placebo controlled trialen_US
dc.typeArticleen_US

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