Protective effects of conventional and colon-targeted lycopene and linalool on ulcerative colitis induced by acetic acid in rats

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dc.authoridAslan, Abdullah/0000-0002-6243-4221
dc.authoridYipel, Mustafa/0000-0002-6390-9313
dc.authoridTekeli, Ibrahim Ozan/0000-0002-6845-2279
dc.authoridATESSAHIN, Ahmet/0000-0002-1004-2146
dc.contributor.authorTekeli, Ibrahim Ozan
dc.contributor.authorAtessahin, Ahmet
dc.contributor.authorSakin, Fatih
dc.contributor.authorAslan, Abdullah
dc.contributor.authorCeribasi, Songul
dc.contributor.authorYipel, Mustafa
dc.date.accessioned2024-09-18T21:00:27Z
dc.date.available2024-09-18T21:00:27Z
dc.date.issued2019
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjectiveTo compare the potential protective effects of conventional and colon-targeted lycopene (TLC) and linalool (TLN) on acetic acid (AA)-induced ulcerative colitis (UC) in rats.MethodsConventional and colon-targeted LC (10mg/kg) and LN (200mg/kg) were administered in vivo orally for 7days and sulfasalazine (100mg/kg) was also used as reference drug. Then, 4% AA was administered intrarectally to induce UC. Subsequently, the colon tissues were taken as samples for biochemical and histopathological analysis.ResultsMalondialdehyde (MDA), interleukin 1 (IL-1), IL-6, cyclooxygenase-2 (COX-2) and nuclear factor kappa B (NF-B) levels were decreased (p<0.05) in the targeted groups compared to the AA group, whereas nuclear factor-erythroid 2-related factor 2 (Nrf-2) level was increased (p<0.05). Tumor necrosis factor (TNF-) level was also decreased (p<0.05) and catalase activity (CAT) was increased (p<0.05) in the TLC group compared to the AA group. IL-1 and IL-6 levels were lower in the TLC group compared to the conventional LC and sulfasalazine groups (p<0.05). COX-2 and NF-B levels were lower, while the Nrf-2 level was higher in the targeted groups compared to the conventional groups (p<0.05). Furthermore, COX-2 level was lower and Nrf-2 level was higher in the targeted groups compared to the sulfasalazine group (p<0.05).ConclusionAs expected, sulfasalazine was effective on all parameters analyzed, but the colon-targeted pretreatments were more effective from sulfasalazine on some parameters. Therefore, colon-targeted plant-derived therapies might be alternative approaches to provide protection against UC, which deserves to be investigated further.en_US
dc.description.sponsorshipScientific Research Projects Coordination of Mustafa Kemal University [14025]en_US
dc.description.sponsorshipThis work was financially supported by Scientific Research Projects Coordination of Mustafa Kemal University (project number: 14025).en_US
dc.identifier.doi10.1007/s10787-018-0485-x
dc.identifier.endpage322en_US
dc.identifier.issn0925-4692
dc.identifier.issn1568-5608
dc.identifier.issue2en_US
dc.identifier.pmid29736689en_US
dc.identifier.scopus2-s2.0-85046531925en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage313en_US
dc.identifier.urihttps://doi.org/10.1007/s10787-018-0485-x
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12699
dc.identifier.volume27en_US
dc.identifier.wosWOS:000465595000010en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Basel Agen_US
dc.relation.ispartofInflammopharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectUlcerative colitisen_US
dc.subjectColon targetingen_US
dc.subjectLycopeneen_US
dc.subjectLinaloolen_US
dc.subjectRaten_US
dc.titleProtective effects of conventional and colon-targeted lycopene and linalool on ulcerative colitis induced by acetic acid in ratsen_US
dc.typeArticleen_US

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