Does Varicocele Repair Improve Conventional Semen Parameters? A Meta-Analytic Study of Before-After Data

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dc.authoridAltay, Baris/0000-0002-3101-8022
dc.authoridBusetto, Gian Maria/0000-0002-7291-0316
dc.authoridRajmil, Osvaldo/0000-0003-1987-9206
dc.authoridKhalafalla, Kareim/0000-0001-9476-4869
dc.authoridSaini, Pallavi/0000-0003-0072-5573
dc.authoridDang, Anh/0000-0002-2317-6493
dc.authoridKOTHARI, PRIYANK/0000-0002-3940-952X
dc.contributor.authorCannarella, Rossella
dc.contributor.authorShah, Rupin
dc.contributor.authorHamoda, Taha Abo-Almagd Abdel-Meguid
dc.contributor.authorBoitrelle, Florence
dc.contributor.authorSaleh, Ramadan
dc.contributor.authorGul, Murat
dc.contributor.authorRambhatla, Amarnath
dc.date.accessioned2024-09-18T20:13:19Z
dc.date.available2024-09-18T20:13:19Z
dc.date.issued2024
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPurpose: The purpose of this meta-analysis is to study the impact of varicocele repair in the largest cohort of infertile males with clinical varicocele by including all available studies, with no language restrictions, comparing intra-person conventional semen parameters before and after the repair of varicoceles. Materials and Methods: The meta-analysis was performed according to PRISMA-P and MOOSE guidelines. A systematic search was performed in Scopus, PubMed, Cochrane, and Embase databases. Eligible studies were selected according to the PICOS model (Population: infertile male patients with clinical varicocele; Intervention: varicocele repair; Comparison: intra-person before-after varicocele repair; Outcome: conventional semen parameters; Study type: randomized controlled trials [RCTs], observational and case-control studies). Results: Out of 1,632 screened abstracts, 351 articles (23 RCTs, 292 observational, and 36 case-control studies) were includ-ed in the quantitative analysis. The before-and-after analysis showed significant improvements in all semen parameters after varicocele repair (except sperm vitality); semen volume: standardized mean difference (SMD) 0.203, 95% CI: 0.129-0.278; p<0.001; I2=83.62%, Egger's p=0.3329; sperm concentration: SMD 1.590, 95% CI: 1.474-1.706; p<0.001; I2=97.86%, Egger's p<0.0001; total sperm count: SMD 1.824, 95% CI: 1.526-2.121; p<0.001; I2=97.88%, Egger's p=0.0063; total motile sperm count: SMD 1.643, 95% CI: 1.318-1.968; p<0.001; I2=98.65%, Egger's p=0.0003; progressive sperm motil-ity: SMD 1.845, 95% CI: 1.537%-2.153%; p<0.001; I2=98.97%, Egger's p<0.0001; total sperm motility: SMD 1.613, 95% CI 1.467%-1.759%; p<0.001; l2=97.98%, Egger's p<0.001; sperm morphology: SMD 1.066, 95% CI 0.992%-1.211%; p<0.001; I2=97.87%, Egger's p=0.1864. Conclusions: The current meta-analysis is the largest to date using paired analysis on varicocele patients. In the current meta-analysis, almost all conventional semen parameters improved significantly following varicocele repair in infertile patients with clinical varicocele.en_US
dc.identifier.doi10.5534/wjmh.230034
dc.identifier.endpage132en_US
dc.identifier.issn2287-4208
dc.identifier.issn2287-4690
dc.identifier.issue1en_US
dc.identifier.pmid37382284en_US
dc.identifier.scopus2-s2.0-85175731583en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage92en_US
dc.identifier.urihttps://doi.org/10.5534/wjmh.230034
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9089
dc.identifier.volume42en_US
dc.identifier.wosWOS:001023750600001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKorean Soc Sexual Medicine & Andrologyen_US
dc.relation.ispartofWorld Journal of Mens Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectControlled before-after studiesen_US
dc.subjectInfertilityen_US
dc.subjectmaleen_US
dc.subjectMeta-analysisen_US
dc.subjectVaricoceleen_US
dc.titleDoes Varicocele Repair Improve Conventional Semen Parameters? A Meta-Analytic Study of Before-After Dataen_US
dc.typeArticleen_US

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