Effect of Remote Ischemic Postconditioning on Left Ventricular Mechanics

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dc.authoridTanboga, Ibrahim Halil/0000-0003-4546-9227
dc.contributor.authorNacar, Alper Bugra
dc.contributor.authorTopcu, Selim
dc.contributor.authorKurt, Mustafa
dc.contributor.authorTanboga, Ibrahim Halil
dc.contributor.authorKarakas, Mehmet Fatih
dc.contributor.authorBuyukkaya, Eyup
dc.contributor.authorAksakal, Enbiya
dc.date.accessioned2024-09-18T20:28:11Z
dc.date.available2024-09-18T20:28:11Z
dc.date.issued2015
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackgroundRemote ischemic postconditioning (RIPC) decreases infarct size and prevents left ventricular (LV) remodeling in patients with myocardial infarction. However, there is no study that evaluates the effect of RIPC on LV mechanics assessed by speckle tracking echocardiography. Therefore, we aimed to test the effects of RIPC on LV deformation parameters such as strain, strain rate, rotation, and twist in healthy subjects. MethodsThe study group consisted of 22 healthy subjects. To test the effects of RIPC, 3 cycles of reperfusion followed by ischemia (each lasting 10 or 30seconds) were applied immediately after 20minutes of nondominant arm ischemia. Transthoracic echocardiography (TTE) was obtained at baseline and repeated 30minutes after the completion of these cycles. In TTE images, apical 4-3-2 chamber longitudinal strain (LS)/strain rate, basal and apical circumferential strain/strain rate, and rotational parameters, such as basal rotation, apical rotation, and LV twist, were recorded. ResultsApical 4-3-2 chamber LS and apical circumferential strain/strain rate measurements were comparable before and after RIPC, whereas basal circumferential strain was significantly decreased after RIPC (-233.4 vs. -18.9 +/- 6.9, P=0.017). After RIPC, apical rotation was significantly increased (11.6 +/- 3.7 vs. 16.7 +/- 4.0, P<0.001) and basal rotation was significantly decreased (-6.1 +/- 2.1 vs. -4.7 +/- 2.4, P=0.03).Consequently, net LV twist was significantly increased (17.4 +/- 4.5 vs. 21.7 +/- 4.7). ConclusionsWe proposed that RIPC affects the rotational mechanics of the heart rather than longitudinal mechanics. These results might give new insights into understanding the favorable effects of the post- conditioning.en_US
dc.identifier.doi10.1111/echo.12677
dc.identifier.endpage453en_US
dc.identifier.issn0742-2822
dc.identifier.issn1540-8175
dc.identifier.issue3en_US
dc.identifier.pmid25041581en_US
dc.identifier.scopus2-s2.0-84924527225en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage448en_US
dc.identifier.urihttps://doi.org/10.1111/echo.12677
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10777
dc.identifier.volume32en_US
dc.identifier.wosWOS:000350655900007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofEchocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniquesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectischemic postconditioningen_US
dc.subjectechocardiographyen_US
dc.subjectleft ventricular deformationen_US
dc.titleEffect of Remote Ischemic Postconditioning on Left Ventricular Mechanicsen_US
dc.typeArticleen_US

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