Association between periodontal diseases and COVID-19 infection: a case-control study with a longitudinal arm

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dc.authoridSari, Aysegul/0000-0001-6180-9776
dc.authoriddikmen, nursel/0000-0002-5923-400X
dc.contributor.authorSari, Aysegul
dc.contributor.authorDikmen, Nursel Kaya
dc.contributor.authorNibali, Luigi
dc.date.accessioned2024-09-18T20:54:10Z
dc.date.available2024-09-18T20:54:10Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractSome studies have suggested potential relationships between periodontal disease and COVID-19, explained by many possible pathological pathways. The aim of this case-control study with a longitudinal arm was to investigate this association. 80 systemically healthy individuals (apart from COVID-19) were involved in this study, divided into 40 patients who had recently had COVID-19 (test, divided into severe and mild/moderate cases) and 40 who had not had COVID-19 (control). Clinical periodontal parameters and laboratory data were recorded. Mann-Whitney U test, Wilcoxon test, and chi-square test were performed to compare variables. Multiple binary logistic regression method was used to estimate adjusted ORs and 95% confidence interval. Hs-CRP-1 and 2, Ferritin-1 and 2, lymphocyte count-1 values, and neutrophil/lymphocyte ratio-1 were higher in patients with severe COVID-19 than patients with mild/moderate COVID-19 (p < 0.05). All of these laboratory values significantly decreased after COVID-19 treatment (p < 0.05) in the test group. Presence of periodontitis (p = 0.015) was higher and periodontal health was lower (p = 0.002) in the test group than in the control group. All clinical periodontal parameters were significantly higher in the test group than in the control group (p < 0.05), except plaque index. Prevalence of periodontitis was associated with increased odds of having COVID-19 infection (PR = 1.34; 95% CI 0.23-2.45) in the multiple binary logistic regression. COVID-19 is associated with periodontitis prevalence, through a series of possible mechanisms including local and systemic inflammatory responses. Further studies should investigate whether the maintenance of periodontal health may be a factor in the reduction of the severity of COVID-19 infections.en_US
dc.identifier.doi10.1007/s10266-023-00797-x
dc.identifier.endpage1017en_US
dc.identifier.issn1618-1247
dc.identifier.issn1618-1255
dc.identifier.issue4en_US
dc.identifier.pmid36867280en_US
dc.identifier.scopus2-s2.0-85149307635en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1009en_US
dc.identifier.urihttps://doi.org/10.1007/s10266-023-00797-x
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11642
dc.identifier.volume111en_US
dc.identifier.wosWOS:000943032200001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofOdontologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPeriodontal diseaseen_US
dc.subjectPeriodontitisen_US
dc.subjectCOVID-19en_US
dc.subjectCytokine stormen_US
dc.titleAssociation between periodontal diseases and COVID-19 infection: a case-control study with a longitudinal armen_US
dc.typeArticleen_US

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