Protective Effects of Caffeic Acid Phenethyl Ester on the Dose-Dependent Acute Nephrotoxicity with Paraquat in a Rat Model

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dc.authorid, ahmet/0000-0001-6274-5700
dc.authoridSefil, Fatih/0000-0001-5534-7448
dc.contributor.authorRifaioglu, Murat Mehmet
dc.contributor.authorSefil, Fatih
dc.contributor.authorGokce, Hasan
dc.contributor.authorNacar, Ahmet
dc.contributor.authorDorum, Bayram Ali
dc.contributor.authorDavarci, Mursel
dc.date.accessioned2024-09-18T20:55:39Z
dc.date.available2024-09-18T20:55:39Z
dc.date.issued2015
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractParaquat (PQ), which is used extensively as a potent herbicide throughout the world, is highly toxic in humans. We aimed to determine PQ-induced biochemical and histologic changes in the kidneys, and to evaluate the ability of the protective effects of caffeic acid phenethyl ester (CAPE) against PQ-induced injury in rats. Forty-eight rats were divided into eight groups of six: Group 1: Control; Group 2: 10 mol/kg CAPE; Group 3: 15 mg/kg PQ; Group 4: 30 mg/kg PQ; Group 5: 45 mg/kg PQ; Group 6: 15 mg/kg PQ+CAPE; Group 7: 30 mg/kg PQ+CAPE; Group 8: 45 mg/kg PQ+CAPE. PQ and CAPE were injected intraperitoneally. The levels of the total oxidant status (TOS) and total antioxidant status (TAS) were determined in the supernatants of the excised left kidney. Right kidney tissue of each rat was removed to obtain a histologic score. When PQ-administrated (15, 30, 45) groups compared with other groups, TOS values were found to be significantly higher (p<0.01). PQ (15, 30, 45) groups had significantly diminished values of TAS than the other groups (p<0.001). Of histologic score evaluation, only the PQ45 group had a significantly higher value than the sham, and CAPE groups (p<0.05). Moreover, in CAPE+PQ45 group, the level of histologic score was decreased compared to PQ45 group (p<0.001). In conclusion, the evaluation of the data suggests that CAPE can be used to prevent the acute effects of PQ nephrotoxicity. (c) 2013 Wiley Periodicals, Inc. Environ Toxicol 30: 375-381, 2015.en_US
dc.identifier.doi10.1002/tox.21915
dc.identifier.endpage381en_US
dc.identifier.issn1520-4081
dc.identifier.issn1522-7278
dc.identifier.issue3en_US
dc.identifier.pmid24265188en_US
dc.identifier.scopus2-s2.0-84921822503en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage375en_US
dc.identifier.urihttps://doi.org/10.1002/tox.21915
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11982
dc.identifier.volume30en_US
dc.identifier.wosWOS:000349178300013en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofEnvironmental Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectraten_US
dc.subjectcaffeic acid phenethyl esteren_US
dc.subjectCAPEen_US
dc.subjectkidneyen_US
dc.subjectparaquaten_US
dc.titleProtective Effects of Caffeic Acid Phenethyl Ester on the Dose-Dependent Acute Nephrotoxicity with Paraquat in a Rat Modelen_US
dc.typeArticleen_US

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