Effect of Topical Application and/or Systemic Use of Red Ginseng Extract on Wound Healing in Rats With Experimentally Induced Diabetes

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dc.contributor.authorDuymus, Mehmet Esat
dc.contributor.authorAydin, Hulya Ayik
dc.contributor.authorBulgurcu, Abdullah
dc.contributor.authorBayramoglu, Zeynep
dc.contributor.authorDurhan, Abdullah
dc.contributor.authorSalih, Salih
dc.contributor.authorPekcici, Mevlut Recep
dc.date.accessioned2024-09-18T20:55:42Z
dc.date.available2024-09-18T20:55:42Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBACKGROUND: Red ginseng (Rg) is an herbal product that has been used in traditional medicine in Asian and European countries for many years. PURPOSE: To study the effects of Rg extract on wound healing when used systemically, locally, or in combination in rats with experimentally induced diabetes. METHODS: A total of 60 rats were randomly divided into 4 groups: saline (control), local Rg (LRg), systemic Rg (SRg), and local + systemic = combined Rg (CRg). A full-thickness wound (2 cm x 1 cm) was created on the back of the rats, and treatment protocols were carried out for 14 days. Wound areas of all rats were measured on days 0 and 14. Tissue samples were taken from the wound areas for histopathologic evalu-ation of inflammation, epithelialization, and fibrosis. Vascular endothelial growth factor (VEGF), CD4+, and CD8+ expressions were examined by immunohistochemistry. RESULTS: Wound contraction measurements were 63.8%, 80.5%, 88.5%, and 86.6% in the control, LRg, SRg and CRg groups, respectively.Although significant differences were observed for all treated groups (LRg, SRg, and CRg) compared with the control group in terms of wound contraction, there was no difference among the treatment groups. VEGF-positive vessel/mm2 was observed 4.00 +/- 0.75, 5.93 +/- 0.70, 5.93 +/- 1.93, and 7.93 +/- 0.70 in the control, LRg, SRg and CRg groups, respectively. There was no difference between LRg and SRg in terms of VEGF expression, but there was significant difference for all other groups compared with each other. CONCLUSION: All usage methods of Rg extract increased wound contraction, and differences were observed compared with the control group. However, the au-thors believe that the combined usage was more effective due to higher VEGF expression levels and lower CD4+:CD8+ ratio.en_US
dc.identifier.doi10.25270/wmp.2022.6.2837
dc.identifier.endpage37en_US
dc.identifier.issn2640-5237
dc.identifier.issn2640-5245
dc.identifier.issue6en_US
dc.identifier.pmid35895033en_US
dc.identifier.scopus2-s2.0-85135380794en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage28en_US
dc.identifier.urihttps://doi.org/10.25270/wmp.2022.6.2837
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12008
dc.identifier.volume68en_US
dc.identifier.wosWOS:000836231800003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHmpen_US
dc.relation.ispartofWound Management & Preventionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectred ginsengen_US
dc.subjectvascular endothelial growth factoren_US
dc.subjectwound healingen_US
dc.subjectdiabetesen_US
dc.subjectanimal studyen_US
dc.titleEffect of Topical Application and/or Systemic Use of Red Ginseng Extract on Wound Healing in Rats With Experimentally Induced Diabetesen_US
dc.typeArticleen_US

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