Effects of ceftriaxone on ischemia/reperfusion injury in rat brain

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dc.authoridOkuyan, Hamza Malik/0000-0001-7616-3330
dc.authorid, ahmet/0000-0001-6274-5700
dc.authoridUlutas, Kemal Turker/0000-0003-2852-0449
dc.authoridMEYDAN, SEDAT/0000-0002-1393-3235
dc.contributor.authorAltas, M.
dc.contributor.authorMeydan, S.
dc.contributor.authorAras, M.
dc.contributor.authorYilmaz, N.
dc.contributor.authorUlutas, K. T.
dc.contributor.authorOkuyan, H. M.
dc.contributor.authorNacar, A.
dc.date.accessioned2024-09-18T20:06:11Z
dc.date.available2024-09-18T20:06:11Z
dc.date.issued2013
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the effect of ceftriaxone treatment against short-term global brain ischemia/reperfusion (I/R) injury in rats. The study was carried out on 30 Wistar-albino rats that were divided into three groups: control group (n = 10), I/R group (n = 10) and I/R-ceftriaxone group (n = 10). Malondialdehyde (MDA) levels were significantly increased in the I/R group in comparison with the control group (p < 0.001). MDA was significantly lower in the I/R-ceftriaxone group than in the I/R group (p < 0.05). Superoxide dismutase activity was significantly decreased in the I/R group and increased in the I/R-ceftriaxone group as compared with the control group. Glutathione peroxidase activity was significantly decreased in the I/R group and increased in the I/R-ceftriaxone group as compared with the I/R group and the control. Histopathologically, ceftriaxone provided morphological improvement compared with the I/R group. We concluded that ceftriaxone has neuron-protective effects due to its antioxidant properties as shown by a decrease in MDA overproduction and histological improvement in brain tissue. (C) 2012 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.jocn.2012.05.030
dc.identifier.endpage461en_US
dc.identifier.issn0967-5868
dc.identifier.issn1532-2653
dc.identifier.issue3en_US
dc.identifier.pmid23219825en_US
dc.identifier.scopus2-s2.0-84875226790en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage457en_US
dc.identifier.urihttps://doi.org/10.1016/j.jocn.2012.05.030
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8348
dc.identifier.volume20en_US
dc.identifier.wosWOS:000316839900025en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofJournal of Clinical Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBrainen_US
dc.subjectCeftriaxoneen_US
dc.subjectIschemiaen_US
dc.titleEffects of ceftriaxone on ischemia/reperfusion injury in rat brainen_US
dc.typeArticleen_US

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