The protective effect of esculetin against aluminium chloride-induced reproductive toxicity in rats

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dc.authoridKUZU, Muslum/0000-0002-1375-7673
dc.authoridGUVENC, MEHMET/0000-0002-9716-0697
dc.authoridTekeli, Ibrahim Ozan/0000-0002-6845-2279
dc.authoridOzkan, Huseyin/0000-0001-5753-8985
dc.contributor.authorTurk, Erdinc
dc.contributor.authorOzan Tekeli, Ibrahim
dc.contributor.authorOzkan, Huseyin
dc.contributor.authorUyar, Ahmet
dc.contributor.authorCellat, Mustafa
dc.contributor.authorKuzu, Muslum
dc.contributor.authorYavas, Ilker
dc.date.accessioned2024-09-18T19:54:15Z
dc.date.available2024-09-18T19:54:15Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractOne of the prominent health problems caused by Aluminium was the decrease in male fertility rates. In the study, the protective effect of Esculetin (ESC) against the reproductive toxicity induced by Aluminium chloride (AlCl3) was investigated. For this purpose, AlCl3 was administrated to Wistar Albino rats at a dose of 34 mg/kg and ESC was administrated at a dose of 50 mg/kg for 70 days. It was determined that AlCl3 treatment reduced sperm motility and concentration, increased dead/live rate and abnormal sperm rate. It decreased serum testosterone level, and co-treatment of ESC significantly regulated these values. In the AlCl3-treated group, MDA level increased and GSH level, GPx and CAT activities decreased compared with those of the control group. However, co-treatment of ESC showed an amelioratory effect on the values except for CAT activity. It was observed that the expression level of NRF-2 increased in the ESC and AlCl3 + ESC groups, and NF-kappa B increased in the AlCl3 group with the control group. It was determined that Caspase-3 expression decreased, and Bcl-2 expression increased in AlCl3 + ESC group compared to AlCl3 group. It was also determined that AlCl3-induced tissue injury was significantly prevented by ESC co-treatment.en_US
dc.description.sponsorshipMustafa Kemal Universitesi [18.M.095]en_US
dc.description.sponsorshipMustafa Kemal Universitesi, Grant/Award Number: 18.M.095en_US
dc.identifier.doi10.1111/and.13930
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue2en_US
dc.identifier.pmid33368464en_US
dc.identifier.scopus2-s2.0-85099521053en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1111/and.13930
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7589
dc.identifier.volume53en_US
dc.identifier.wosWOS:000601330700001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAndrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectaluminium chlorideen_US
dc.subjectesculetinen_US
dc.subjectoxidative stressen_US
dc.subjectreproductive toxicityen_US
dc.subjectsperm qualityen_US
dc.titleThe protective effect of esculetin against aluminium chloride-induced reproductive toxicity in ratsen_US
dc.typeArticleen_US

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