Safety and efficacy of tirofiban hydrochloride (TH) in cerulein-induced acute pancreatitis

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dc.authorscopusid56683930100
dc.authorscopusid35621697200
dc.authorscopusid57197568884
dc.authorscopusid8988852800
dc.authorscopusid54584171000
dc.authorscopusid56804807800
dc.authorscopusid8336280500
dc.contributor.authorKaplan, Aydin
dc.contributor.authorAkkucuk, Seckin
dc.contributor.authorUgur, Mustafa
dc.contributor.authorAydogan, Akin
dc.contributor.authorOzgur, Tumay
dc.contributor.authorCaliskan, Yasemin
dc.contributor.authorYetim, Ibrahim
dc.date.accessioned2024-09-19T15:41:25Z
dc.date.available2024-09-19T15:41:25Z
dc.date.issued2015
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIntroduction: Tissue perfusion plays an important role in pancreatitis. Free oxygen radicals also have some triggering roles in the severity of acute pancreatitis. Tirofiban hydrochloride (TH) is being used for ischemic disorders for many years and is known as an antiaggregant drug. We aimed to determine the therapeutic effects of tirofiban in cerulein-induced acute pancreatitis in this animal study. Materials and methods: Twenty-four Wistar-Albino male rats were divided into three equal groups; Group I: Sham-operated group, Group II: cerulein induced pancreatitis group, Group III: cerulein induced pancreatitis + treatment group (intraperitoneal 0.25 mg tirofiban hydrochloride in 1 ml isotonic saline solution). Amylase and lipase levels were studied in blood samples and malondialdehyde, glutathione peroxidase and superoxide dismutase activities were measured in tissue samples. Results: Amylase and lipase levels were elevated in acute pancreatitis group. The levels of both enzymes were decreased after the rats were medicated with TH. Malondialdehyde (MDA) was higher in pancreatitis group without treatment. There were no significant differences between groups according to glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) levels. Conclusion: The present findings suggest that TH has an antiaggregant effect and may reduce the progression and improve the healing of acute pancreatitis.en_US
dc.identifier.endpage1257en_US
dc.identifier.issn0393-6384
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-84950245002en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1253en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14248
dc.identifier.volume31en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherA. CARBONE Editoreen_US
dc.relation.ispartofActa Medica Mediterraneaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute pancreatitisen_US
dc.subjectGlycoprotein IIb-IIIa inhibitoren_US
dc.subjectReactive oxygen speciesen_US
dc.subjectTirofiban hydrochlorideen_US
dc.titleSafety and efficacy of tirofiban hydrochloride (TH) in cerulein-induced acute pancreatitisen_US
dc.typeArticleen_US

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