Caffeic acid phenethyl ester (CAPE) protects against acute urogenital injury following pneumoperitoneum in the rat

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dc.authorid, ahmet/0000-0001-6274-5700
dc.authoridKaplan Sefil, Nebihat/0000-0003-0091-8471
dc.contributor.authorRifaioglu, Murat Mehmet
dc.contributor.authorDavarci, Mursel
dc.contributor.authorNacar, Ahmet
dc.contributor.authorAlp, Harun
dc.contributor.authorCelik, Murat
dc.contributor.authorSefil, Nebihat Kaplan
dc.contributor.authorInci, Mehmet
dc.date.accessioned2024-09-18T20:06:21Z
dc.date.available2024-09-18T20:06:21Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPurpose: Our aim is to determine the biochemical and histologic changes induced in the kidneys, testis and prostate on possible ischemia and reperfusion (I/R) injury caused by pneumoperitoneum (PNP) in a rat model and to evaluate the ability of protective effects of caffeic acid phenethyl ester (CAPE). Methods: Twenty-eight adult male Wistar albino rats were randomly divided to one of three treatment groups, with seven animals in each group. Sham, laparoscopy (L), and laparoscopy plus CAPE (L + C) group were subjected to 60 min of PNP with 15 mmHg one hour before the desufflation period. Total oxidant status (TOS) and total antioxidant status (TAS) levels were determined in kidney, testis, and prostate. Kidney and testis tissues were removed to obtain a histologic score. Also, Johnsen scoring system was used for testicular tissue analysis. Results: L group had significantly higher TOS and lower TAS levels on kidney and testis compared to the other groups. In prostate biochemical analysis, there was not any difference between groups. No difference was found between groups according to kidney and testis tissues' histologic evaluation. In evaluation of Johnsen scoring, L group showed significant lower score compared to the other two groups. Conclusions: Increased intraabdominal pressure (IAP) had an oxidative effect on kidney and testis but not on prostate in rats. Moreover, it could affect the testicular Johnsen score. All these adverse effects of IAP on both kidney and testis could be prevented by CAPE administration.en_US
dc.identifier.doi10.3109/0886022X.2013.832317
dc.identifier.endpage103en_US
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue1en_US
dc.identifier.pmid24028427en_US
dc.identifier.scopus2-s2.0-84889609563en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage98en_US
dc.identifier.urihttps://doi.org/10.3109/0886022X.2013.832317
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8474
dc.identifier.volume36en_US
dc.identifier.wosWOS:000327875200020en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofRenal Failureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCaffeic acid phenethyl esteren_US
dc.subjectkidneyen_US
dc.subjectprostateen_US
dc.subjectpneumoperitoneumen_US
dc.subjectraten_US
dc.subjecttestisen_US
dc.titleCaffeic acid phenethyl ester (CAPE) protects against acute urogenital injury following pneumoperitoneum in the raten_US
dc.typeArticleen_US

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