Potential neoplastic effects of parathion-methyl on rat liver
Yükleniyor...
Tarih
2009
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Science Press
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The mutagenic and carcinogenic effects of parathion-methyl were examined by bacterial reverse mutation assay and a long-term experiment with wistar rats. The potential mutagenic effect of parathion-methyl in Salmonella typhimurium TA100 bacterial cells was observed without rat liver S9 metabolic activation. Parathion-methyl was further investigated for pathological changes in rat pancreas and liver. The long-term rat experiments showed that parathion-methyl exposure for 3 months can cause pathological changes in rat pancreases acinar cells and pancreatic hepatocytes. Atypical acinar cell focuses (AACF) were determined in the liver and pancreas of the rats. The results from short-term Ames test and long-term rat experiments suggested that parathion-methyl would be potential carcinogenic.
Açıklama
Anahtar Kelimeler
atypical acinar cell focuses, Ames test, carcinogenesis, parathion-methyl
Kaynak
Journal of Environmental Sciences
WoS Q Değeri
N/A
Scopus Q Değeri
Q1
Cilt
21
Sayı
5
