Is a Cholestrol-Enriched Diet a Risk Factor for Alveolar Bone Loss?

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dc.authoridOzmen, Ozlem/0000-0002-1835-1082
dc.contributor.authorKirzioglu, Fatma Yesim
dc.contributor.authorFentoglu, Ozlem
dc.contributor.authorBulut, Memduha Tozum
dc.contributor.authorDogan, Burak
dc.contributor.authorOzdem, Muhsin
dc.contributor.authorOzmen, Ozlem
dc.contributor.authorCarsancakli, Suleyman Akif
dc.date.accessioned2024-09-18T19:54:15Z
dc.date.available2024-09-18T19:54:15Z
dc.date.issued2016
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: This study aims to investigate the effects of a 2% cholesterol-enriched diet on alveolar bone loss (ABL) and serum levels of pro-oxidants and antioxidant enzymes in rats with experimental periodontitis. Methods: Rats were randomized into the four groups: 1) group C (standard diet/periodontally healthy); 2) group Hc (high-cholesterol diet); 3) group HcP (high-cholesterol diet/periodontitis); and 4) group P (standard diet/periodontitis). All rats were fed for 8 weeks. At 6 weeks, experimental periodontitis was induced. At the end of week 8, the rats were sacrificed. Histomorphometric and histopathologic analyses were performed. Malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase, and glutathione peroxidase (GPX) levels in serum were measured with enzyme-linked immunosorbent assay. Results: Experimental groups exhibited increases in: 1) total cholesterol, 2) low-density lipoprotein, and 3) high-density lipoprotein compared to group C. The cholesterol-enriched diet induced ABL in group Hc; groups HcP and P had more extensive ABL. The most polymorphonuclear leukocyte infiltration in periodontal tissues was found in group HcP. MDA levels were higher in all experimental groups than in group C, but significant in the HcP group. A high-cholesterol diet, with or without periodontitis, resulted in more decreases in GPX and more increases in NO compared to group P. Conclusion: Although any additive effect of cholesterol-enriched diet to ABL was not found in rats with ligature-induced experimental periodontitis, these findings revealed that a cholesterol-enriched diet could lead to ABL and an increase in periodontal inflammation and serum pro-oxidants.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey [213S105]; Scientific Research Foundation of Suleyman Demirel University Project [3424-D1-13]en_US
dc.description.sponsorshipThe authors thank Drs. Sulhattin Yasar and Serkan Boyar, Associate Professors, and their staff at the Departments of Agriculture Machinery and Animal Science, Suleyman Demirel University, Isparta, Turkey, for technical support. This work was supported by Scientific and Technological Research Council of Turkey Project 213S105 and Scientific Research Foundation of Suleyman Demirel University Project 3424-D1-13. The authors report no conflicts of interest related to this study.en_US
dc.identifier.doi10.1902/jop.2016.150509
dc.identifier.endpage538en_US
dc.identifier.issn0022-3492
dc.identifier.issn1943-3670
dc.identifier.issue5en_US
dc.identifier.pmid26751342en_US
dc.identifier.scopus2-s2.0-84964674951en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage529en_US
dc.identifier.urihttps://doi.org/10.1902/jop.2016.150509
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7596
dc.identifier.volume87en_US
dc.identifier.wosWOS:000375843400009en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Periodontologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlveolar bone lossen_US
dc.subjectcholesterolen_US
dc.subjectglutathione peroxidaseen_US
dc.subjectmalondialdehydeen_US
dc.subjectoxidative stressen_US
dc.subjectperiodontitisen_US
dc.titleIs a Cholestrol-Enriched Diet a Risk Factor for Alveolar Bone Loss?en_US
dc.typeArticleen_US

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