Serum dehydroepiandrosterone sulphate level in age-related macular degeneration

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dc.contributor.authorTamer, Cengaver
dc.contributor.authorOksuz, Huseyin
dc.contributor.authorSogut, Sadik
dc.date.accessioned2024-09-18T21:03:01Z
dc.date.available2024-09-18T21:03:01Z
dc.date.issued2007
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPURPOSE: To evaluate plasma dehydroepiandrosterone sulphate (DHEAS) levels in patients diagnosed with age-related macular degeneration (AMD) and controls. DESIGN: Case-controlled, prospective, comparative noninterventional study. METHODS: This study involved 32 men and 35 women with exudative AMD, 37 men and 38 women with nonexudative AMD, and 32 men and 32 women of an age,matched control group. The Wisconsin Age,Related Maculopathy Grading System was used to asses the severity of AMD lesions. DHEAS levels were measured and compared according to a gender based subdivision Analysis of variance was used to assess the association between DHEAS and AMD. Linear regression model was used to examine the relation among DHEAS level and AMD severity scale. RESULTS: Mean +/- SD of DHEAS levels in exudative AMD, nonexudative AMD, and controls in men was 2.67 +/- 0.68 mu mol/l, 2.89 +/- 0.95 mu mol/l, and 4.43 +/- 1.44 mu mol/l, respectively (P =.001), and in women was 1.64 +/- 0.72 mu mol/l, 1.85 +/- 0.73 mu mol/l, and 2.78 +/- 0.91 mu mol/l, respectively (P = .001). Post hoc Tukey analyses revealed a significant reduction in serum DHEAS level in both AMD groups, compared with controls for men and women (P =.001), while no difference was found between AMD groups in both men and women (P = .668 and 0.49, respectively). Regres, sion analyses revealed an inverse correlation among serum DHEAS level and AMD severity scale both in men and women (P = .006 and .007, respectively). CONCLUSIONS: This study suggests an inverse correlation between serum DHEAS level and AMD severity scale with a considerably reduced DHEAS level in AMD.en_US
dc.identifier.doi10.1016/j.ajo.2006.09.054
dc.identifier.endpage216en_US
dc.identifier.issn0002-9394
dc.identifier.issue2en_US
dc.identifier.pmid17157799en_US
dc.identifier.scopus2-s2.0-33846381647en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage212en_US
dc.identifier.urihttps://doi.org/10.1016/j.ajo.2006.09.054
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13202
dc.identifier.volume143en_US
dc.identifier.wosWOS:000244271400003en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofAmerican Journal of Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHigh-Dose Supplementationen_US
dc.subjectPigment Epithelial-Cellsen_US
dc.subjectOxidative Stressen_US
dc.subjectClinical-Trialen_US
dc.subjectBeta-Caroteneen_US
dc.subjectSex-Hormonesen_US
dc.subjectVision Lossen_US
dc.subjectVitamin-Cen_US
dc.subjectDamageen_US
dc.subjectPathogenesisen_US
dc.titleSerum dehydroepiandrosterone sulphate level in age-related macular degenerationen_US
dc.typeArticleen_US

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