Determination of oxidative stress and effect of erdosteine on rhinitis medicamentosa in a rat model

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dc.authoridSefil, Fatih/0000-0001-5534-7448
dc.authoridYonden, Zafer/0000-0003-0708-5417
dc.authoridDokuyucu, Recep/0000-0001-6837-3477
dc.authoridDokuyucu, Recep/0000-0001-7881-8871
dc.contributor.authorDokuyucu, Recep
dc.contributor.authorCevik, Cengiz
dc.contributor.authorOzler, Gul Soylu
dc.contributor.authorOzgur, Tumay
dc.contributor.authorArli, Cengiz
dc.contributor.authorSefil, Fatih
dc.contributor.authorYonden, Zafer
dc.date.accessioned2024-09-18T20:55:49Z
dc.date.available2024-09-18T20:55:49Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractWe aimed to determine the presence of oxidative stress in rhinitis medicamentosa (RM) and to evaluate the effect of erdosteine (ED) on mucosal changes in a rat model. Twenty-four male rats were used in this experimental study. Three groups were created. Group 1 (n=8) was the control group. Two puffs of 0.05% oxymetazolin were sprayed into the nasal cavities of the remaining rats (n = 16) three times daily for eight weeks. One of these 16 rats was scarified at the end of the eight weeks and examined to confirm the presence of RM. Seven of the remaining 16 rats were killed, and venous blood samples were taken (Group 2). Group 3 (n=8) received 10 mg/kg of an ED suspension orally for seven days. All rats were put on formalin for light microscopy. The total antioxidant status (TAS) was similar in all groups (p = 0.073). The total oxidative status (TOS) of the RM group was significantly higher than that of the control group and RM + ED group (Group 3) (p = 0.003 and p = 0.011, respectively). The pathological recovery of the nasal mucosa of the rats was similar in the RM + ED and control groups. The TOS was high in this RM rat model, and oxidative stress was associated with RM. ED significantly ameliorated nasal mucosal changes induced by RM, suggesting that oxidative stress may play an important role in the pathophysiology of this condition. (C) 2014 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.ejphar.2014.09.009
dc.identifier.endpage157en_US
dc.identifier.issn0014-2999
dc.identifier.issn1879-0712
dc.identifier.pmid25240710en_US
dc.identifier.scopus2-s2.0-84926330209en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage153en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejphar.2014.09.009
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12063
dc.identifier.volume742en_US
dc.identifier.wosWOS:000345526600021en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofEuropean Journal of Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRhinitis medicamentosaen_US
dc.subjectTotal antioxidant statusen_US
dc.subjectTotal oxidative statusen_US
dc.subjectErdosteinen_US
dc.subjectExperimental studyen_US
dc.titleDetermination of oxidative stress and effect of erdosteine on rhinitis medicamentosa in a rat modelen_US
dc.typeArticleen_US

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