Bilateral high frequency stimulation of the subthalamic nucleus normalizes COX activity in the substantia nigra of Parkinsonian rats

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dc.authoridKaplan, Suleyman/0000-0003-1477-5002
dc.contributor.authorVlamings, Rinske
dc.contributor.authorVisser-Vandewalle, Veerle
dc.contributor.authorKozan, Ramazan
dc.contributor.authorKaplan, Suleyman
dc.contributor.authorSteinbusch, Harry W. M.
dc.contributor.authorTemel, Yasin
dc.date.accessioned2024-09-18T20:59:10Z
dc.date.available2024-09-18T20:59:10Z
dc.date.issued2009
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPart of the mechanism underlying the therapeutic effect of subthalamic nucleus (STN) high frequency stimulation (HFS) involves the activity of the basal ganglia output structures. The general idea is that STN's burst activity leads to an increased activity of the basal ganglia output nuclei and that HFS reverses this. However, the published data sets conflict. Here, we addressed the question which effect STN HFS had on the overall substantia nigra pars reticulata (SNr; one of the basal ganglia output nuclei) activity, in rats rendered Parkinsonian by 6-hydroxydopamine (6-OHDA) injections in the striatum, We used a marker for metabolic activity, cytochrome C oxidase (COX). The expression of COX in the SNr of Parkinsonian rats was significantly higher as compared to sham-operated rats. However, in Parkinsonian rats with STN HFS, expression of COX was significantly lower as compared to non-stimulated Parkinsonian rats, and was comparable to the level of expression in sham-operated rats. These results show that STN HFS decreased the overall activity of the basal ganglia output nucleus in dopamine-depleted rats. (C) 2009 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipPrinses Beatrix Fonds [WAR06-0110]; Dutch Brain Foundation (Hersenstichting Nederland) [2008(1).32]; Netherlands Organisation for Scientific Research [016.096.032]en_US
dc.description.sponsorshipThe authors are grateful to Mrs. Hellen Steinbusch and Mrs. Hatice Ozen for their technical assistance. This study was funded by the Prinses Beatrix Fonds (grant no: WAR06-0110), Dutch Brain Foundation (Hersenstichting Nederland, grant no: 2008(1).32), and The Netherlands Organisation for Scientific Research (NWO-Veni grant no: 016.096.032).en_US
dc.identifier.doi10.1016/j.brainres.2009.06.091
dc.identifier.endpage148en_US
dc.identifier.issn0006-8993
dc.identifier.issn1872-6240
dc.identifier.pmid19596282en_US
dc.identifier.scopus2-s2.0-69049104020en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage143en_US
dc.identifier.urihttps://doi.org/10.1016/j.brainres.2009.06.091
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12428
dc.identifier.volume1288en_US
dc.identifier.wosWOS:000270104200016en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofBrain Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSubthalamic nucleusen_US
dc.subjectHigh frequency stimulationen_US
dc.subjectSubstantia nigraen_US
dc.subjectcytochrome C oxidaseen_US
dc.subjectParkinson's diseaseen_US
dc.titleBilateral high frequency stimulation of the subthalamic nucleus normalizes COX activity in the substantia nigra of Parkinsonian ratsen_US
dc.typeArticleen_US

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