Paced Corrected QT Interval is Associated with Lv Diastolic Dysfunction in Patients With Permanent Pacemakers and Preserved Left Ventricular Ejection Fraction

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dc.contributor.authorKaypakli, Onur
dc.date.accessioned2024-09-18T20:53:04Z
dc.date.available2024-09-18T20:53:04Z
dc.date.issued2018
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: Although chronic right ventricular apex (RVA) pacing is usually well tolerated in patients with normal cardiac function, recent studies report that not only left ventricular (LV) systolic function but also diastolic function is adversely affected. The aim of the present study was to detect the relationship between paced QRS, paced corrected QT (pQTc) duration, and echocardiographic parameters of LV diastolic dysfunction to examine the effects of RVA pacing in patients with preserved LV ejection fraction (LVEF). Methods: We included 74 patients with LVEF>50% and DDD(R) pacemakers implanted for atrioventricular block (45 men and 29 women; mean age 64.9 +/- 11.6 years). Patients were included to the study at least 6 months after battery implantation. Patients with RVA pacing rate <70% were excluded from the study. Patients were classified into two groups according to the left atrial (LA) volume index. Results: pQTc was associated with LA volume index, LA volume, LA end-diastolic diameter, E-wave deceleration time, septal annular e' velocity, and mitral E/e' ratio in bivariate analysis. The cut-off value of pQTc obtained by receiver operating characteristic curve analysis was 512 ms for prediction of increased (>34 mL/m(2)) LA volume index (sensitivity: 88.0% and specificity: 79.6%). The area under the curve was 0.848 (p<0.001). Conclusion: pQTc duration was found to be significantly associated with the echocardiographic parameters of LV diastolic dysfunction. We suggest that pQTc be used as a marker to predict the risk of diastolic dysfunction after permanent pacemaker implantation in patients with preserved LVEF. It can also be used to optimize the RV pacing area with intraoperative measurements.en_US
dc.identifier.doi10.5152/EurJTher.2018.447
dc.identifier.endpage53en_US
dc.identifier.issn2564-7784
dc.identifier.issn2564-7040
dc.identifier.issue1en_US
dc.identifier.startpage49en_US
dc.identifier.urihttps://doi.org/10.5152/EurJTher.2018.447
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11562
dc.identifier.volume24en_US
dc.identifier.wosWOS:000436145200009en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherAves Press Ltden_US
dc.relation.ispartofEuropean Journal of Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPaced QT intervalen_US
dc.subjectcardiac pacingen_US
dc.subjectpaced qrs widthen_US
dc.titlePaced Corrected QT Interval is Associated with Lv Diastolic Dysfunction in Patients With Permanent Pacemakers and Preserved Left Ventricular Ejection Fractionen_US
dc.typeArticleen_US

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