Role of adiponectin and leptin in patients with alopecia areata with scalp hair loss

Basit Öğe Kaydı
dc.contributor.authorSerarslan, Gamze
dc.contributor.authorOzcan, Oguzhan
dc.contributor.authorOkyay, Ebru
dc.contributor.authorUnlu, Bahar
dc.contributor.authorKaradag, Mehmet
dc.date.accessioned2024-09-18T19:50:23Z
dc.date.available2024-09-18T19:50:23Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground/aims Alopecia areata (AA) is considered an organ-specific autoimmune disease of hair follicles. Adipose tissue plays a role in lipid metabolism and glucose metabolism and secretes adipokines such as leptin and adiponectin. Dysregulation in the adipokine balance may be associated with metabolic syndrome. We aimed to determine serum adipokine levels in AA patients and compare them with healthy controls, and to determine whether there was metabolic syndrome and insulin resistance in the AA patients. Methods A total of 70 participants were included in the study. Patients were divided into two subgroups: patients with scalp hair loss were in subgroup 1 (AA1). Patients with beard and eyebrow hair loss were in subgroup 2 (AA2). Serum adiponectin, leptin, TNF-alpha, insulin, fasting glucose, TG, and HDL were analyzed. Results Thirty-six (25 male, 11 female) patients with AA and 34 (18 male, 16 female) healthy subjects were included in the study. Metabolic syndrome was detected in three of the AA patients and in two of the healthy subjects. Serum leptin, adiponectin, TNF-alpha, TG, HDL, and insulin levels and HOMA-IR scores were not statistically significant in patients compared with control subjects, except fasting glucose levels (p = 0.035). However, serum leptin and adiponectin levels were significantly higher in AA1 (n = 25) subgroup compared with the control group (p = 0.029,p = 0.026 respectively). There was a statistically significant increase in the fasting glucose level, while there were no differences in other parameters between the AA2 (n = 11) subgroup and the control group. Conclusions To our knowledge, this is the first report indicating that adiponectin and leptin probably has a role in the pathogenesis of AA with scalp hair involvement.en_US
dc.description.sponsorshipScientific Research Project Unit of Hatay Mustafa Kemal Universityen_US
dc.description.sponsorshipThis work was supported by the Scientific Research Project Unit of Hatay Mustafa Kemal University.en_US
dc.identifier.doi10.1007/s11845-020-02410-4
dc.identifier.endpage1020en_US
dc.identifier.issn0021-1265
dc.identifier.issn1863-4362
dc.identifier.issue3en_US
dc.identifier.pmid33083959en_US
dc.identifier.scopus2-s2.0-85092780309en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1015en_US
dc.identifier.urihttps://doi.org/10.1007/s11845-020-02410-4
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7403
dc.identifier.volume190en_US
dc.identifier.wosWOS:000580744200002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer London Ltden_US
dc.relation.ispartofIrish Journal of Medical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdipokineen_US
dc.subjectAdiponectinen_US
dc.subjectAlopecia areataen_US
dc.subjectLeptinen_US
dc.titleRole of adiponectin and leptin in patients with alopecia areata with scalp hair lossen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ N/A ]
İsim:
7403.pdf
Boyut:
210.61 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu