Maternal l-thyroxine treatment during lactation affects learning and anxiety-like behaviors but not spatial memory in adult rat progeny

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dc.contributor.authorTan, Burak
dc.contributor.authorBakkaloglu, Umut
dc.contributor.authorAscioglu, Meral
dc.contributor.authorSuer, Cem
dc.date.accessioned2024-09-18T20:29:28Z
dc.date.available2024-09-18T20:29:28Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground The present study compared behavioral and molecular indicators of hippocampal function in l-thyroxine treated rats to determine whether thyroid hormone excessiveness produces relatively stable lifelong changes. Methods Hyperthyroidism was induced in rats by daily injections of l-thyroxine (0.2 mg/kg) to their dams for lactation period (MOH: maternal-onset hyperthyroidism) or to the rats itself during the young adult period (AOH: adult-onset hyperthyroidism; between the day 39-60). Spatial learning was assessed in the Morris Water Maze (MWM). Levels of type 2 and type 3 deiodinases, Erk1/2, JNK and P38(MAPK) were assessed via western blotting in the hippocampus of trained rats. Measurements were all done in rats aged 60-66 days. Results In MWM, maternally treated rats with l-thyroxine swam more away from the hidden platform, with showing more anxiety-like behavior, as compared to the rats treated or no treated with l-thyroxine in young adulthood. In spite of impaired acquisition, MOH group was not significantly different from the other groups in probe trial. In Western blot of the hippocampus, a decreased the expression of P38MAPK was found in rats treated with l-thyroxine in young adulthood period. However, maternal treatment with l-thyroxine resulted in an increased expression of Type 2 deiodinase and a tendency toward decreased expression of total and phosphorylated ERK1/2. No detectable band for type 3 deiodinase, p-JNK and p-P38(MAPK) was observed in all three groups. Conclusion These results suggest that perinatal excessiveness of thyroid hormone has longstanding effects on hippocampal function and may account for memory problems experienced by adolescents with lactational hyperthyroidism.en_US
dc.description.sponsorshipErciyes University Research Fund [TYL-2014-5377]en_US
dc.description.sponsorshipThis work was supported by the Erciyes University Research Fund [Grant numbers: TYL-2014-5377].en_US
dc.identifier.doi10.1007/s43440-020-00214-y
dc.identifier.endpage463en_US
dc.identifier.issn1734-1140
dc.identifier.issn2299-5684
dc.identifier.issue2en_US
dc.identifier.pmid33481209en_US
dc.identifier.scopus2-s2.0-85099973194en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage454en_US
dc.identifier.urihttps://doi.org/10.1007/s43440-020-00214-y
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10856
dc.identifier.volume73en_US
dc.identifier.wosWOS:000609989300002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofPharmacological Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLactational hyperthyroidismen_US
dc.subjectLearning and memoryen_US
dc.subjectHippocampusen_US
dc.subjectMorris water mazeen_US
dc.titleMaternal l-thyroxine treatment during lactation affects learning and anxiety-like behaviors but not spatial memory in adult rat progenyen_US
dc.typeArticleen_US

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