Genotoxic and cytotoxic effects of flumetralin in human peripheral blood lymphocytes in vitro

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dc.contributor.authorKocaman, Ayse Yavuz
dc.contributor.authorBucak, Sevcan
dc.date.accessioned2024-09-18T20:08:24Z
dc.date.available2024-09-18T20:08:24Z
dc.date.issued2016
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractFlumetralin, a synthetic plant growth regulator with herbicidal activity belonging to the 2,6-dinitroaniline class of chemicals, has been evaluated for its ability to induce genotoxicity in human peripheral blood lymphocytes (PBLs). The potential genotoxic and cytotoxic effects of flumetralin were investigated in vitro by chromosome aberration (CA) and cytokinesis-block micronucleus assays. Human PBLs were treated with 125, 250, 500, and 1000 mu g/mL flumetralin for 24 and 48 h. Flumetralin statistically significantly increased the frequency of structural CAs at the three highest concentrations (250, 500, and 1000 mu g/mL) for both treatment periods (24 and 48 h) when compared with both the negative and solvent controls. In addition, micronucleus formation was significantly induced at higher concentrations (250, 500, and 1000 mu g/mL) for 24 h and at 125 and 500 mu g/mL of flumetralin for the 48-h treatment period compared with the controls. Because of the excessive cytostatic effects of flumetralin, binuclear cells could not be detected sufficiently at the highest two concentrations (500 and 1000 mu g/mL) for the 48-h treatment period. Furthermore, flumetralin significantly decreased the mitotic index and nuclear division index for all concentrations and treatment times compared with the control groups. The present results indicate that flumetralin was clastogenic and cytotoxic/cytostatic to human PBLs. This study presents the first report of the genotoxic and cytotoxic properties of flumetralin.en_US
dc.description.sponsorshipMustafa Kemal University Research Fund [282]en_US
dc.description.sponsorshipThis study was supported by Mustafa Kemal University Research Fund (project code: 282).en_US
dc.identifier.doi10.1177/0748233715595142
dc.identifier.endpage1934en_US
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue12en_US
dc.identifier.pmid26319234en_US
dc.identifier.scopus2-s2.0-85000842784en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1927en_US
dc.identifier.urihttps://doi.org/10.1177/0748233715595142
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8812
dc.identifier.volume32en_US
dc.identifier.wosWOS:000389113500002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofToxicology and Industrial Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChromosome aberrationsen_US
dc.subjectcytotoxicityen_US
dc.subjectflumetralinen_US
dc.subjectgenotoxicityen_US
dc.subjectmicronucleusen_US
dc.titleGenotoxic and cytotoxic effects of flumetralin in human peripheral blood lymphocytes in vitroen_US
dc.typeArticleen_US

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