Serum pregnancy-associated glycoprotein profiles during early gestation in Karya and Konya Merino sheep

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dc.authoridAKKOSE, MEHMET/0000-0001-7517-4927
dc.authoridKaya, Ufuk/0000-0002-4805-0993
dc.authoridCINAR, Elif Merve/0000-0003-0684-7213
dc.authoridcebi, cigdem/0000-0001-6876-2069
dc.authoridOZBEYAZ, CEYHAN/0000-0002-3748-9992
dc.contributor.authorAkkose, Mehmet
dc.contributor.authorCinar, Elif Merve
dc.contributor.authorYazlik, Murat Onur
dc.contributor.authorKaya, Ufuk
dc.contributor.authorPolat, Yadigar
dc.contributor.authorCebi, Cigdem
dc.contributor.authorOzbeyaz, Ceyhan
dc.date.accessioned2024-09-18T20:19:56Z
dc.date.available2024-09-18T20:19:56Z
dc.date.issued2024
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackgroundReported as being expressed by mono- and binucleate placental cells, pregnancy-associated glycoproteins (PAGs) are released into the blood circulation from the ruminant placenta. Circulating gestational PAGs levels may differ between sheep breeds.ObjectiveThis study was aimed at the close monitoring of the serum PAGs profiles of Karya and Konya Merino sheep during early pregnancy.MethodsFifteen Karya and 15 Konya Merino ewes were synchronized by a 12-day treatment with progesterone-impregnated intravaginal sponges. After the sponges were withdrawn, the ewes were administered 400 IU of equine chorionic gonadotropin. The ewes were allowed to mate naturally, and all animals were sampled for blood as of the day of mating (day 0) at weeks 1, 2, 3, 4 and 5. Pregnancy diagnoses were made by transabdominal ultrasonography at week 5. At weeks 6, 7, 8, 9 and 11, blood samples were collected only from the pregnant ewes. The blood samples were centrifuged at 3000 x g, and extracted sera were stored at -20 degrees C until being used for laboratory analyses. Serum PAGs levels were determined with the aid of a commercial PAG-enzyme-linked immunosorbent assay test originally developed for pregnancy diagnosis in cattle. Differences in the between the PAGs levels throughout pregnancy and the group effect (Karya and Konya Merino) were determined with a two-way mixed analysis of variance. Pairwise comparisons were made using a Bonferroni adjustment.ResultsPAGs levels showed a linear increase with the advance of pregnancy in both Karya and Konya Merino sheep. No difference was detected between the breeds for serum PAGs levels. The serum PAGs levels of the pregnant and non-pregnant ewes differed as of the fourth week.ConclusionThe serum PAGs levels of the Karya and Konya Merino ewes were similar during the first 11 weeks of gestation, and pregnancy diagnosis could be made based on serum PAGs levels as of the 4th week in both breeds. Graphical Abstract: Pregnant Karya and Konya Merino ewes display similar pregnancy-associated glycoproteins (PAGs) profile. Serum PAGs levels increased gradually in both breed during first 11 weeks of pregnancy. Pregnant and non-pregnant ewes can be differentiated as of the fourth week of gestation based on serum PAG levels. imageen_US
dc.identifier.doi10.1002/vms3.1345
dc.identifier.issn2053-1095
dc.identifier.issue1en_US
dc.identifier.pmid38227703en_US
dc.identifier.scopus2-s2.0-85182487777en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1002/vms3.1345
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9957
dc.identifier.volume10en_US
dc.identifier.wosWOS:001142589800001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofVeterinary Medicine and Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjecteween_US
dc.subjectgestationen_US
dc.subjectmanagementen_US
dc.subjectpregnancy diagnosisen_US
dc.subjectserumen_US
dc.titleSerum pregnancy-associated glycoprotein profiles during early gestation in Karya and Konya Merino sheepen_US
dc.typeArticleen_US

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