Relationship between Insulin Resistance and Inflamation Markers in Hemodialysis Patients

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dc.contributor.authorBorazan, Ali
dc.contributor.authorBinici, Dogan Nasir
dc.date.accessioned2024-09-18T20:26:39Z
dc.date.available2024-09-18T20:26:39Z
dc.date.issued2010
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective. The prevalence and risk factors of cardiovascular disease (CVD) are increasing in end stage renal disease (ESRD) patients. In this study, we sought to research the relationship between the insulin resistance, which is one of the risk factors for CVD, and the inflammation markers, especially Creactive protein, fibrinogen, uric acid, and homocysteine levels in our patients who were recently diagnosed with ESRD and started hemodialysis. Materials and methods. 64 HOMA-IR-positive and 114 HOMA-IR-negative patients were enrolled in this study. Blood samples were obtained from the patients for fasting plasma glucose, insulin, CRP, fibrinogen, uric acid, total homocysteine, urea, total cholesterol, HDL-cholesterol, LDLcholesterol, triglyceride, total protein, and albumin analysis after physical examinations and anamnesis were completed. Results. Fibrinogen and CRP levels of HOMA-IR-positive HD patients were significantly increased compared to non-insulin resistants. Furthermore, there is significant positive relationship between insulin resistance and serum CRP and fibrinogen levels in these HOMA-IR-positive HD patients (r = 0.258, p < 0.001). Conclusion. We found out that the fibrinogen and CRP levels are significantly high in HOMA-IR positive HD patients, according to determine the risk ratio for coronary artery disease in HD patients, and think that an assessment of insulin resistance is necessary.en_US
dc.identifier.doi10.3109/08860220903491232
dc.identifier.endpage202en_US
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue2en_US
dc.identifier.pmid20199182en_US
dc.identifier.scopus2-s2.0-77749254872en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage198en_US
dc.identifier.urihttps://doi.org/10.3109/08860220903491232
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10461
dc.identifier.volume32en_US
dc.identifier.wosWOS:000275111100009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofRenal Failureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjecthemodialysisen_US
dc.subjectinsulin resistanceen_US
dc.subjectC-reactive proteinen_US
dc.subjectfibrinogenen_US
dc.subjecturic aciden_US
dc.subjecthomocysteineen_US
dc.titleRelationship between Insulin Resistance and Inflamation Markers in Hemodialysis Patientsen_US
dc.typeArticleen_US

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