Effects of letrozole on bone biomarkers and femur fracture in female rats

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dc.authoridYilmaz, Bayram/0000-0002-2674-6535
dc.contributor.authorYonden, Z.
dc.contributor.authorAydin, M.
dc.contributor.authorAlcin, E.
dc.contributor.authorKelestemur, M. H.
dc.contributor.authorKutlu, S.
dc.contributor.authorYilmaz, B.
dc.date.accessioned2024-09-18T20:29:33Z
dc.date.available2024-09-18T20:29:33Z
dc.date.issued2009
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractZ. YONDEN, M. AYDIN, E. ALCIN, M.H. KELESTEMUR, S. KUTLU and B. YILMAZ. Effects of letrozole on bone biomarkers and femur fracture in female rats. J Physiol Biochem, 65 (3), 267-276, 2009. We aimed to investigate the effects of the aromatase inhibitor letrozole on femur fracture and serum levels of alkaline phosphatase (ALP), calcium and phosphate in female rats. Intact 32 Sprague-Dawley female rats were divided into four groups (n=8): control, letrozole 0.2, letrozole 1 (treatment of 0.2 and 1 mg/kg for six weeks) and recovery (letrozole-treated 1 mg/kg for six weeks then allowed to recover for two weeks). Besides, 24 ovariectomized rats were divided into three groups (n=8): ovariectomized+control, ovariectomized+letrozole and ovariectomized+letrozole+ estradiol (10 mu g/rat). After experimental period, rats' femur bones were removed for biomechanical studies following decapitation. Serum ALP, calcium and phosphate were measured. Biomechanical values, ALP and phosphate significantly increased by letrozole in a dose-dependent manner (p<0.05) while calcium levels and net bone area decreased (p<0.05). Ultimate strength was positively correlated with ALP and phosphate and negatively correlated with calcium. The results indicate that letrozole may increase risk of bone fracture and affect bone biomarkers such as ALP, calcium and phosphate in both intact and ovariectomized rats.en_US
dc.identifier.doi10.1007/BF03180579
dc.identifier.endpage275en_US
dc.identifier.issn1138-7548
dc.identifier.issue3en_US
dc.identifier.pmid20119821en_US
dc.identifier.scopus2-s2.0-75749091527en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage267en_US
dc.identifier.urihttps://doi.org/10.1007/BF03180579
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10934
dc.identifier.volume65en_US
dc.identifier.wosWOS:000273857700006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherServicio Publicaciones Universidad Navarraen_US
dc.relation.ispartofJournal of Physiology and Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLetrozoleen_US
dc.subjectBiomechanicsen_US
dc.subjectAlkaline phosphataseen_US
dc.subjectCalciumen_US
dc.subjectPhosphateen_US
dc.titleEffects of letrozole on bone biomarkers and femur fracture in female ratsen_US
dc.typeArticleen_US

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