The Effects of Remifentanil and Esmolol on Increase in Intraocular Pressure Due to Laryngoscopy and Tracheal Intubation: A Double-Blind, Randomized Clinical Trial

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dc.contributor.authorTuzcu, Kasim
dc.contributor.authorTuzcu, Esra A.
dc.contributor.authorKarcioglu, Murat
dc.contributor.authorDavarci, Isil
dc.contributor.authorCoskun, Mesut
dc.contributor.authorIlhan, Ozgur
dc.contributor.authorDaglioglu, Mutlu C.
dc.date.accessioned2024-09-18T20:28:09Z
dc.date.available2024-09-18T20:28:09Z
dc.date.issued2015
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPurpose:This study aimed to compare the effects of remifentanil and esmolol on the elevation of intraocular pressure (IOP) and hemodynamic response.Methods:After approval of the institutional Ethics Committee and obtaining informed consent, 60 adult patients with American Society of Anesthesiologists I-II status undergoing elective, nonophthalmic surgery were included in the study. Exclusion criteria were preexisting eye disease, neuromuscular disease, esophageal reflux, hiatus hernia, allergy to any of the study drugs, and the use of -blockers, diuretics, or other antihypertensive agents. The patients were randomized into 2 groups by using the sealed-envelope method, as follows: group E (esmolol) and group R (remifentanil). A single intravenous dose of esmolol (0.5 mg/kg) or remifentanil (1 g/kg) just before induction agents were given to patients in groups E and R, respectively. IOP, heart rate (HR), and mean arterial pressure (MAP) values were recorded before intubation and at 1, 3, 5, and 10 minutes after intubation.Results:The IOP decrease in group R was statistically significant compared with group E (P<0.01). HR values at 10 minutes after intubation were significantly decreased in group E compared with group R (P<0.05). There was no significant difference in MAP values between the groups.Conclusions:It was concluded that remifentanil is more effective than esmolol in preventing IOP elevation related to laryngoscopy and tracheal intubation, while there is no significant difference between the 2 agents in terms of HR and MAP.en_US
dc.description.sponsorshipscientific fund of Mustafa Kemal University [1202M0109]en_US
dc.description.sponsorshipSupported financially by scientific fund of Mustafa Kemal University. Project code: 1202M0109.en_US
dc.identifier.doi10.1097/IJG.0b013e31829f9bfe
dc.identifier.endpage376en_US
dc.identifier.issn1057-0829
dc.identifier.issn1536-481X
dc.identifier.issue5en_US
dc.identifier.pmid23835673en_US
dc.identifier.scopus2-s2.0-84931567530en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage372en_US
dc.identifier.urihttps://doi.org/10.1097/IJG.0b013e31829f9bfe
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10764
dc.identifier.volume24en_US
dc.identifier.wosWOS:000356375400006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal of Glaucomaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectintraocular pressureen_US
dc.subjectremifentanilen_US
dc.subjectesmololen_US
dc.subjecthemodynamic responseen_US
dc.titleThe Effects of Remifentanil and Esmolol on Increase in Intraocular Pressure Due to Laryngoscopy and Tracheal Intubation: A Double-Blind, Randomized Clinical Trialen_US
dc.typeArticleen_US

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