Hepatotoxic activity of toluene inhalation and protective role of melatonin

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dc.authoridOgeturk, Murat/0000-0002-5744-4812
dc.authoridKULOGLU, TUNCAY/0000-0001-9874-3838
dc.authoridILHAN, NECIP/0000-0001-9997-0418
dc.authoridMEYDAN, SEDAT/0000-0002-1393-3235
dc.contributor.authorTas, Ufuk
dc.contributor.authorOgeturk, Murat
dc.contributor.authorMeydan, Sedat
dc.contributor.authorKus, Ilter
dc.contributor.authorKuloglu, Tuncay
dc.contributor.authorIlhan, Necip
dc.contributor.authorKose, Evren
dc.date.accessioned2024-09-18T21:00:20Z
dc.date.available2024-09-18T21:00:20Z
dc.date.issued2011
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThis study was designed to investigate the harmful effects of toluene inhalation in the liver of rats and possible protective effects of melatonin on these detrimental effects. For this purpose, 21 adult male Wistar-albino rats were randomly divided into three equal groups. Animals in group I were used as control. The rats in group II were exposed to toluene (3000 ppm/1 hour/day) for 4 weeks, while the rats in group III were treated with melatonin (10 mg/kg/day, intraperitoneally [ip]) plus toluene inhalation. At the end of the experimental period, liver and blood samples were taken from the decapitated animals. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total bilirubin and albumin levels were determined. Liver tissue sections were stained with routine histological methods and examined under the light microscope. In addition, the sections were immunohistochemically stained using avidin-biotin-peroxidase method for determination of apoptosis. The liver tissue activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) and malondialdehyde (MDA) levels were also measured. Toluene inhalation significantly increased serum ALT, AST and tissue MDA, and decreased serum albumin, but did not affect serum ALP, total bilirubin levels and tissue SOD, GSH-Px and CAT activity when compared with controls. The increases in tissue MDA and serum ALT and AST levels induced by toluene inhalation were significantly inhibited by melatonin treatment. In light microscopic observations of tissues from toluene-inhaled rats, massive hepatocyte degeneration, ballooning degeneration and mild pericentral fibrosis were observed. Bax immune reactivity was also increased significantly. Melatonin treatment decreased the balloon degeneration, fibrosis and Bax immune reactivity in the liver of toluene-inhaled rats. In view of the present findings, it is suggested that melatonin has hepatoprotective effects against toluene toxicity via primarily antioxidative properties.en_US
dc.identifier.doi10.1177/0748233710389853
dc.identifier.endpage473en_US
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue5en_US
dc.identifier.pmid21343225en_US
dc.identifier.scopus2-s2.0-79957666185en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage465en_US
dc.identifier.urihttps://doi.org/10.1177/0748233710389853
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12597
dc.identifier.volume27en_US
dc.identifier.wosWOS:000291038300009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofToxicology and Industrial Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTolueneen_US
dc.subjectmelatoninen_US
dc.subjectliveren_US
dc.subjectapoptosisen_US
dc.subjectimmunohistochemistryen_US
dc.titleHepatotoxic activity of toluene inhalation and protective role of melatoninen_US
dc.typeArticleen_US

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