Correlation of serum galectin-3 level with renal volume and function in adult polycystic kidney disease

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dc.authoridBilgin, Muzaffer/0000-0002-6072-6466
dc.authoridyilmaz, behice kaniye/0000-0001-6842-3323
dc.authoridFIDAN, NURDAN/0000-0002-2995-6220
dc.contributor.authorOzkurt, Sultan
dc.contributor.authorDogan, Ibrahim
dc.contributor.authorOzcan, Oguzhan
dc.contributor.authorFidan, Nurdan
dc.contributor.authorBozaci, Ilter
dc.contributor.authorYilmaz, Behice
dc.contributor.authorBilgin, Muzaffer
dc.date.accessioned2024-09-18T20:02:47Z
dc.date.available2024-09-18T20:02:47Z
dc.date.issued2019
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPurposeThe decrease in kidney functions in autosomal dominant polycystic kidney disease (ADPKD) is strongly correlated with the severity and growth of kidney cysts. Total kidney volume (TKV) was shown to be an early marker of the severity of the disease and a predictor of reduction in kidney functions. New treatment approaches for ADPKD have led to a need for easily applicable strong biomarkers predicting progression of the disease. The profibrotic mediator of galectin-3 (Gal-3) is linked to development of renal fibrosis.MethodsThe study included 74 patients with ADPKD diagnosis and 40 healthy controls. The TKV of patients was calculated using the manual tracing method on MR images. The serum Gal-3 levels of patient and healthy control groups were measured with the ELISA method. The correlations between serum Gal-3 value with TKV and kidney function were assessed in patients.ResultsAs the stage of chronic kidney disease (CKD) increased, serum Gal-3 and TKV values increased (p<0.001, p=0.049, respectively). Correlation analysis found a negative relationship between serum Gal-3 levels and eGFR (r: -0.515, p<0.001); however, there was no relationship between serum Gal-3 and TKV (r=0.112, p=0.344). Linear regression analysis showed the major parameter affecting Gal-3 was eGFR (p=0.016).ConclusionsIn our study, we showed that renal impairment is an important determinant of Gal-3, and there is no correlation of Gal-3 and TKV in ADPKD. As a result, there is an urgent clinical need for new biomarkers to identify individuals with the chance of treatment in the early stage among ADPKD patients.en_US
dc.description.sponsorshipEskisehir Osmangazi University Scientific Research Project [2017-11044]en_US
dc.description.sponsorshipSupported by Eskisehir Osmangazi University Scientific Research Project. Project number: 2017-11044.en_US
dc.identifier.doi10.1007/s11255-019-02156-8
dc.identifier.endpage1197en_US
dc.identifier.issn0301-1623
dc.identifier.issn1573-2584
dc.identifier.issue7en_US
dc.identifier.pmid31012038en_US
dc.identifier.scopus2-s2.0-85064590087en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1191en_US
dc.identifier.urihttps://doi.org/10.1007/s11255-019-02156-8
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8029
dc.identifier.volume51en_US
dc.identifier.wosWOS:000474214700015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofInternational Urology and Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAutosomal dominant polycystic kidney diseaseen_US
dc.subjectFibrosisen_US
dc.subjectGalectin-3en_US
dc.subjectTotal kidney volumeen_US
dc.titleCorrelation of serum galectin-3 level with renal volume and function in adult polycystic kidney diseaseen_US
dc.typeArticleen_US

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