Comparative study of the volume of the temporal lobe sections and neuropeptide effect in Alzheimer's patients and healthy persons

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dc.authoridPETEKKAYA, EMINE/0000-0002-5366-2425
dc.authoridKUS, Berna/0000-0001-8279-0357
dc.contributor.authorPetekkaya, Emine
dc.contributor.authorBurakgazi, Gulen
dc.contributor.authorKus, Berna
dc.contributor.authorMelek, Ismet Murat
dc.contributor.authorArpaci, Abdullah
dc.date.accessioned2024-09-18T19:54:15Z
dc.date.available2024-09-18T19:54:15Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAim The aim of this study was to make a volumetric comparison of some medial temporal lobe structures and neuropeptides between the patients of Alzheimer's disease (AD) and healthy individuals. Method The study comprised of a group of patients diagnosed with mild AD (n:15) and a Control group (n:15) (16 females, 14 males, mean age:72.90 +/- 4.50). Voxel-based morphometry and MRICloud analyses were performed on the MR images taken in 3D measurements of gray matter volumes of all subjects. Following a 10-minute hug test, blood samples were taken from all participants for oxytocin (OT) and arginine vasopressin (AVP) analyses. Results The patient group had a statistically lower right hippocampus volume (p = 0.004) and OT values (p = 0.028) than the Control group. OT signal values increased with a volume increase in the right parahippocampal gyrus (PHG_R), and OT conc. and AVP conc. values increased with increasing volume of the PHG_R. Conclusion It is suggested that the right hippocampus, right fusiform gyrus, left amygdala, left parahippocampal gyrus, and left entorhinal cortex atrophies can be used as predictors in the early diagnosis of AD. The positive correlation between PHG_R and neuropeptides showed the need to investigate the PHG and OT function more deeply.en_US
dc.identifier.doi10.1080/00207454.2020.1831490
dc.identifier.endpage734en_US
dc.identifier.issn0020-7454
dc.identifier.issn1563-5279
dc.identifier.issue8en_US
dc.identifier.pmid33064056en_US
dc.identifier.startpage725en_US
dc.identifier.urihttps://doi.org/10.1080/00207454.2020.1831490
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7603
dc.identifier.volume131en_US
dc.identifier.wosWOS:000578054000001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofInternational Journal of Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectoxytocinen_US
dc.subjectvasopressinen_US
dc.subjecthippocampusen_US
dc.subjectfusiform gyrusen_US
dc.subjectparahippocampal gyrusen_US
dc.titleComparative study of the volume of the temporal lobe sections and neuropeptide effect in Alzheimer's patients and healthy personsen_US
dc.typeArticleen_US

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