Evaluation of IL-23p19/Ebi3 (IL-39) gingival crevicular fluid levels in periodontal health, gingivitis, and periodontitis

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dc.authoridKoseoglu, Serhat/0000-0002-4121-2494
dc.authoridSari, Aysegul/0000-0001-6180-9776
dc.contributor.authorSari, Aysegul
dc.contributor.authorDogan, Serdar
dc.contributor.authorNibali, Luigi
dc.contributor.authorKoseoglu, Serhat
dc.date.accessioned2024-09-18T20:54:10Z
dc.date.available2024-09-18T20:54:10Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjectives IL-23p19/Ebi3 (IL-39) was described as a new IL-12 family member. The aim of this study is to evaluate the gingival crevicular fluid (GCF) IL-39 levels in periodontal diseases and health and to correlate them to GCF levels of IL-1 beta and periostin. Materials and methods Sixty-six adult patients were included in the study. The study design was comprised of three groups, each containing 22 individuals: the periodontally healthy (PH), gingivitis (G), and periodontitis (P) groups. The clinical periodontal parameters were recorded and GCF samples were collected from the participants. GCF interleukin (IL)-39, IL-1 beta, and periostin levels were examined using the enzyme-linked immunosorbent assay. Results GCF IL-1 beta, periostin, and IL-39 levels were higher in the P and G groups than in the PH group (p < 0.001). Positive correlations were detected between all GCF biochemical parameters and clinical periodontal parameters (p < 0.05). In the multivariate generalized linear regression analysis, the P (beta = 37.6, 95% CI = 22.9-52.4) and G (beta = 28.4, 95% CI = 15.8-41) groups were associated with GCF IL-39 levels (p < 0.001). Conclusion IL-39 levels were elevated in the presence of periodontal disease paralleling the increase in IL-1 beta and periostin levels. IL-39 may have a role in the periodontal inflammation process. Statement of clinical relevance IL-39, a new cytokine from the IL-12 family, can be a possible predictor marker of periodontal diseases.en_US
dc.identifier.doi10.1007/s00784-022-04681-w
dc.identifier.endpage7218en_US
dc.identifier.issn1432-6981
dc.identifier.issn1436-3771
dc.identifier.issue12en_US
dc.identifier.pmid35986791en_US
dc.identifier.scopus2-s2.0-85136473629en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage7209en_US
dc.identifier.urihttps://doi.org/10.1007/s00784-022-04681-w
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11643
dc.identifier.volume26en_US
dc.identifier.wosWOS:000842997200002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofClinical Oral Investigationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPeriodontal diseaseen_US
dc.subjectPeriodontitisen_US
dc.subjectInflammationen_US
dc.subjectIL-23p19en_US
dc.subjectEbi3 (IL-39)en_US
dc.subjectCytokineen_US
dc.titleEvaluation of IL-23p19/Ebi3 (IL-39) gingival crevicular fluid levels in periodontal health, gingivitis, and periodontitisen_US
dc.typeArticleen_US

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