Resveratrol, a Natural Antioxidant, Attenuates Intestinal Ischemia/Reperfusion Injury in Rats

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dc.authoridYonden, Zafer/0000-0003-0708-5417
dc.authoridOzkan, Orhan Veli/0000-0002-2862-294X
dc.authorid/0000-0002-1807-6957
dc.contributor.authorOzkan, Orhan Veli
dc.contributor.authorYuzbasioglu, Mehmet Fatih
dc.contributor.authorCiralik, Harun
dc.contributor.authorKurutas, Ergul Beige
dc.contributor.authorYonden, Zafer
dc.contributor.authorAydin, Mehmet
dc.contributor.authorBulbuloglu, Ertan
dc.date.accessioned2024-09-18T20:55:47Z
dc.date.available2024-09-18T20:55:47Z
dc.date.issued2009
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description10th European Congress of Trauma and Emergency Surgery -- MAY 13-17, 2009 -- Antalya, TURKEYen_US
dc.description.abstractThe intestine is highly susceptible to ischemia/reperfusion (I/R) injury. Splanchnic ischemia is the initial event that releases injurious factors, leading to systemic disorders with high morbidity and mortality. Oxidative stress mediators are believed to contribute to the intestinal I/R injury. Resveratrol, a polyphenol found in grapes, is shown to be a strong antioxidant in various tissues, with a property of an estrogen-receptor agonist. Therefore, we investigated the effects of resveratrol on oxidative injury in the intestine. Female Wistar rats were randomly allocated into four groups (n = 8, each). The sham group was only subjected to surgical procedures, while other animals were subjected to intestinal ischemia (60 min) and subsequent reperfusion (60 min). One group received resveratrol (15 mg/kg, 0.3 ml/day intraperitoneally) for both 5 days before surgery and 15 min before ischemia, while the other was treated intraperitoneally with 0.5% ethyl alcohol as vehicle (0.3 ml/day). In the I/R rat intestines, we detected severe tissure injuries (p < 0.001), the significant increases in the tissue levels of malondialdehyde (MDA), nitric oxide (NO), and myeloperoxidase (MPO) (p < 0.001), and the decrease in superoxide dismutase (SOD) activity (p < 0.001), compared to the sham control. Resveratrol significantly ameliorated the intestinal injury, decreased MDA, NO and MPO levels to the sham control levels, and decreased bacterial translocation in mesentery lymp nodes, liver and spleen (p < 0.001). Resveratrol also restored the SOD activity. These results suggest that resveratrol could protect intestinal tissue against I/R injury with its potent antioxidant properties.en_US
dc.identifier.doi10.1620/tjem.218.251
dc.identifier.endpage258en_US
dc.identifier.issn0040-8727
dc.identifier.issn1349-3329
dc.identifier.issue3en_US
dc.identifier.pmid19561396en_US
dc.identifier.scopus2-s2.0-68849086743en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage251en_US
dc.identifier.urihttps://doi.org/10.1620/tjem.218.251
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12048
dc.identifier.volume218en_US
dc.identifier.wosWOS:000267787900012en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTohoku Univ Medical Pressen_US
dc.relation.ispartofTohoku Journal of Experimental Medicineen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectResveratrolen_US
dc.subjectintestinal ischemia/reperfusion injuryen_US
dc.subjectantioxidantsen_US
dc.subjecthistopathological evaluationen_US
dc.subjectbacterial translocationen_US
dc.titleResveratrol, a Natural Antioxidant, Attenuates Intestinal Ischemia/Reperfusion Injury in Ratsen_US
dc.typeConference Objecten_US

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