Exploring of the ameliorative effects of Nerium (Nerium oleander L.) ethanolic flower extract in streptozotocin induced diabetic rats via biochemical, histological and molecular aspects

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dc.authoridCelik, Ismail/0000-0003-2199-6348
dc.authoridaslan, ali/0000-0002-5122-6646
dc.authoriddogan, abdulahad/0000-0002-5438-8560
dc.authoridDemir, Abdulbaki/0000-0002-6867-4410
dc.authoridBaloglu, Mehmet Cengiz/0000-0003-2976-7224
dc.authoridKELES, OMER FARUK/0000-0002-7869-5311
dc.authoridUyar, Ahmet/0000-0003-4345-6756
dc.contributor.authorBattal, Abdulhamit
dc.contributor.authorDogan, Abdulahad
dc.contributor.authorUyar, Ahmet
dc.contributor.authorDemir, Abdulbaki
dc.contributor.authorKeles, oemer Faruk
dc.contributor.authorCelik, Ismail
dc.contributor.authorBaloglu, Mehmet Cengiz
dc.date.accessioned2024-09-18T20:25:09Z
dc.date.available2024-09-18T20:25:09Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground Nerium oleander L. is ethnopharmacologically used for diabetes. Our aim was to investigate the ameliorative effects of ethanolic Nerium flower extract (NFE) in STZ-induced diabetic rats.Methods Seven random groups including control group, NFE group (50 mg/kg), diabetic group, glibenclamide group and NFE treated groups (25 mg/kg, 75 mg/kg, and 225 mg/kg) were composed of forty-nine rats. Blood glucose level, glycated hemoglobin (HbA1c), insulin level, liver damage parameters and lipid profile parameters were investigated. Antioxidant defense system enzyme activities and reduced glutathione (GSH) and malondialdehyde (MDA) contents and immunotoxic and neurotoxic parameters were determined in liver tissue. Additionally, the ameliorative effects of NFE were histopathologically examined in liver. mRNA levels of SLC2A2 gene encoding glucose transporter 2 protein were measured by quantitative real time PCR.Results NFE caused decrease in glucose level and HbA1c and increase in insulin and C-peptide levels. Additionally, NFE improved liver damage biomarkers and lipid profile parameters in serum. Moreover, lipid peroxidation was prevented and antioxidant enzyme activities in liver were regulated by NFE treatment. Furthermore, anti-immunotoxic and anti-neurotoxic effects of NFE were determined in liver tissue of diabetic rats. Histopathogically, significant liver damages were observed in the diabetic rats. Histopathological changes were decreased partially in the 225 mg/kg NFE treated group. SLC2A2 gene expression in liver of diabetic rats significantly reduced compared to healthy rats and NFE treatment (25 mg/kg) caused increase in gene expression.Conclusion Flower extract of Nerium plant may have an antidiabetic potential due to its high phytochemical content. [Graphics] .en_US
dc.description.sponsorshipVan Yuezuencue Yil University Scientific Research Coordination Unit [TSA-2017-5927, TSA-2016-5097]en_US
dc.description.sponsorshipThis work was supported by Van Yuezuencue Yil University Scientific Research Coordination Unit with grant numbers (TSA-2017-5927) and (TSA-2016-5097).en_US
dc.identifier.doi10.1007/s11033-023-08332-5
dc.identifier.endpage4205en_US
dc.identifier.issn0301-4851
dc.identifier.issn1573-4978
dc.identifier.issue5en_US
dc.identifier.pmid36897524en_US
dc.identifier.scopus2-s2.0-85149762790en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage4193en_US
dc.identifier.urihttps://doi.org/10.1007/s11033-023-08332-5
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10113
dc.identifier.volume50en_US
dc.identifier.wosWOS:000947251400002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofMolecular Biology Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFlower extracten_US
dc.subjectGLUT2en_US
dc.subjectNerium oleanderen_US
dc.subjectStreptozotocinen_US
dc.titleExploring of the ameliorative effects of Nerium (Nerium oleander L.) ethanolic flower extract in streptozotocin induced diabetic rats via biochemical, histological and molecular aspectsen_US
dc.typeArticleen_US

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