Effect of phosphodiesterase-5 inhibitor on hearing

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dc.contributor.authorOkuyucu, S.
dc.contributor.authorGuven, O. E.
dc.contributor.authorAkoglu, E.
dc.contributor.authorUcar, E.
dc.contributor.authorDagli, S.
dc.date.accessioned2024-09-18T21:00:32Z
dc.date.available2024-09-18T21:00:32Z
dc.date.issued2009
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: Following a report of sudden hearing loss in a patient taking phosphodiesterase type 5 inhibitor, and a Food and Drug Administration announcement concerning this class of drugs, a study was planned to investigate if ototoxicity occurs in patients using phosphodiesterase 5 inhibitor for erectile dysfunction. Methods: Eighteen patients with erectile dysfunction who had been using phosphodiesterase 5 inhibitor were included in the study. Audiometric tests were performed on all patients, between the frequencies 250 and 16 000 Hz, before and 1, 5 and 72 hours after drug ingestion. Results: Four patients showed a unilateral threshold decrease compatible with ototoxicity criteria; this change was reversible. A statistically significant difference in pre- versus post-drug hearing thresholds was observed in the right ear at 10 000 Hz (p = 0.008). There were no statistically significant hearing threshold differences at any other frequencies (p > 0.05). Conclusion: Although temporary ototoxicity was noted in four patients, we could not find any permanent, deleterious effect of phosphodiesterase type 5 inhibitor on hearing thresholds.en_US
dc.identifier.doi10.1017/S002221510900423X
dc.identifier.endpage722en_US
dc.identifier.issn0022-2151
dc.identifier.issn1748-5460
dc.identifier.issue7en_US
dc.identifier.pmid19134242en_US
dc.identifier.scopus2-s2.0-68149126337en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage718en_US
dc.identifier.urihttps://doi.org/10.1017/S002221510900423X
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12748
dc.identifier.volume123en_US
dc.identifier.wosWOS:000267952500004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCambridge Univ Pressen_US
dc.relation.ispartofJournal of Laryngology and Otologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectVardenafilen_US
dc.subjectSensorineural Deafnessen_US
dc.subjectDrug Toxicityen_US
dc.titleEffect of phosphodiesterase-5 inhibitor on hearingen_US
dc.typeArticleen_US

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