The genotoxic and antigenotoxic potential of the methanolic root extract of Glycyrrhiza glabra L. on human peripheral blood lymphocytes

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dc.authoridYAVUZ KOCAMAN, Ayse/0000-0001-7700-784X
dc.contributor.authorKocaman, Ayse Yavuz
dc.contributor.authorGuzelkokar, Muge
dc.date.accessioned2024-09-18T20:25:25Z
dc.date.available2024-09-18T20:25:25Z
dc.date.issued2018
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractGlycyrrhiza glabra L. (licorice) is one of the most important medicinal plants, which is widely used throughout the world both in traditional and contemporary medical industries. This study was undertaken to investigate the potential genotoxic activity of G. glabra methanolic root extract, and its possible antigenotoxic properties against mitomycin C (MMC)-induced DNA damage in in vitro chromosome aberrations (CAs) and cytokinesis-block micronucleus (CBMN) assays in human peripheral blood lymphocytes (PBLs). Lymphocytes were treated with 25, 50, and 100 mu g/ml G. glabra methanolic root extract alone as well as in combination with MMC (0.1 mu g/ml) for 24 and 48 h treatment periods. It was found that there were no statistically significant differences between the negative control and the groups treated with all concentrations of G. glabra root extract of alone (p > 0.05), demonstrating the absence of genotoxic effects at both 24 and 48 h treatment periods. Besides, the co-treatment of G. glabra methanolic root extract and MMC significantly decreased the percentage of structural CAs and MN formation when compared with the culture treated with MMC alone (p < 0.001). In addition, the negative interaction factor (IF) values obtained for all combinations represent an antagonistic effect of G. glabra versus MMC. We can state that this extract acts as an antagonist and markedly decreased MMC-induced cytogenotoxicity. In conclusion, the present results demonstrate that in the tested experimental conditions, G. glabra methanolic root extract is not genotoxic in cultured human PBLs and has also antigenotoxic activity against MMC, which is widely used in chemotherapy against cancer.en_US
dc.description.sponsorshipMustafa Kemal University Scientific Research Projects [10701]en_US
dc.description.sponsorshipThis work was funded by the Mustafa Kemal University Scientific Research Projects [project code: 10701].en_US
dc.identifier.doi10.1080/01480545.2018.1435686
dc.identifier.endpage375en_US
dc.identifier.issn0148-0545
dc.identifier.issn1525-6014
dc.identifier.issue3en_US
dc.identifier.pmid29447011en_US
dc.identifier.scopus2-s2.0-85042083712en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage368en_US
dc.identifier.urihttps://doi.org/10.1080/01480545.2018.1435686
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10298
dc.identifier.volume41en_US
dc.identifier.wosWOS:000435675100014en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofDrug and Chemical Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGlycyrrhiza glabra L.en_US
dc.subjectgenotoxicityen_US
dc.subjectantigenotoxicityen_US
dc.subjectchromosome aberrationen_US
dc.subjectmicronucleusen_US
dc.subjectblood lymphocytesen_US
dc.titleThe genotoxic and antigenotoxic potential of the methanolic root extract of Glycyrrhiza glabra L. on human peripheral blood lymphocytesen_US
dc.typeArticleen_US

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