CHEMICAL COMPOSITION OF ESSENTIAL OILS FROM Origanum onites L. AND Cymbopogon citratus, AND THEIR SYNERGISTIC EFFECTS WITH ACYCLOVIR AGAINST HSV-1

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dc.authoridKaya, Durmus Alpaslan/0000-0003-3544-9214
dc.contributor.authorDuran, Nizami
dc.contributor.authorKaya, Durmus Alpaslan
dc.date.accessioned2024-09-18T19:50:21Z
dc.date.available2024-09-18T19:50:21Z
dc.date.issued2018
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description7th International Conference on Advanced Materials and Systems -- OCT 18-20, 2018 -- Bucharest, ROMANIAen_US
dc.description.abstractOriganum onites L. and Cymbopogon citratus have a number of pharmacological activities such as antimicrobial, anti-inflammatory and antioxidant. In this study, we aimed to investigate the components and the synergistic effect of Origanum onites L. and Cymbopogon citratus and their combinations with acyclovir against HSV-1 on HEp-2 cell line. The main essential oil components of Origanum onites L. were Thymol (68,28%), gamma-Terpinene (5,50%), p-Cymene (5,47%) and Linalool (4,40%) and for Cymbopogon citratus the main components were E-Citral (47,53%), Z-Citral (36,29%), beta-Myrcene (9,31%). Initially, 100 TCID50 (Tissue Culture Infective Dose) of HSV-1 on HEp-2 was calculated in the study. Antiviral activity studies were carried out at the concentration of 1, 10 and 100 TCID50 of HSV-1. The antimicrobial efficacy of the Origanum onites L. and Cymbopogon citratus essential oils were assessed alone and in combination with acyclovir. In addition, the efficacy of acyclovir was determined on 100 TCID50 of HSV-1. In conclusion, the essential oils of Origanum onites L. and Cymbopogon citratus against HVS-1 were found to have a significant inhibitory effect on viral replication. We think that the essential oils of Origanum onites L. and Cymbopogon citratus may be a very important agent against herpesviruses. In particular, the essential oils of Cymbopogon citratus can be a very promising plant.en_US
dc.description.sponsorshipMinist Res & Innovat,Natl Res & Dev Inst Textile & Leather, Div Leather & Footwear Res Insten_US
dc.identifier.doi10.24264/icams-2018.IV.1
dc.identifier.endpage248en_US
dc.identifier.scopus2-s2.0-85111849530en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage243en_US
dc.identifier.urihttps://doi.org/10.24264/icams-2018.IV.1
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7383
dc.identifier.wosWOS:000464905000038en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherIncdtp-Icpien_US
dc.relation.ispartofProceedings of The 7th International Conference on Advanced Materials and Systemsen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcycloviren_US
dc.subjectHSV-1en_US
dc.subjectLinaloolen_US
dc.subjectrosmarinic aciden_US
dc.subjectHEp-2 cell lineen_US
dc.subjectantiviralen_US
dc.titleCHEMICAL COMPOSITION OF ESSENTIAL OILS FROM Origanum onites L. AND Cymbopogon citratus, AND THEIR SYNERGISTIC EFFECTS WITH ACYCLOVIR AGAINST HSV-1en_US
dc.typeConference Objecten_US

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