Association of miR-21-5p with routine biochemical markers and inflammatory cytokines in hemodialysis patients

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dc.authoridOkuyan, Hamza Malik/0000-0001-7616-3330
dc.contributor.authorOkuyan, Hamza Malik
dc.contributor.authorTerzi, Menderes Yusuf
dc.contributor.authorDogan, Serdar
dc.contributor.authorEmir, Tuerkan
dc.contributor.authorTurgut, Faruk Hilmi
dc.date.accessioned2024-09-18T20:08:26Z
dc.date.available2024-09-18T20:08:26Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: Although the role of miR-21-5p in some kidney diseases is relatively documented, the relationship of miR-21-5p with markers of bone metabolism and inflammation in patients receiving hemodialysis (HD) remains unclear. Here, we aim to explore the relationship of miR-21-5p with routine biochemical parameters, mineral bone disorders, and inflammatory markers in HD patients. Methods: Serum miR-21-5p expressions from 60 HD patients and 20 healthy controls were analyzed with qPCR. Bone metabolism-related parameters such as receptor activator of nuclear factor-kappa B ligand (RANKL), osteocalcin, calcium, phosphorus, and parathormone; inflammation-related markers such as tumor necrosis factor-alpha (TNF-& alpha;), interleukin (IL)-6, IL-10, and C-reactive protein (CRP); and oxidative stress markers such as total antioxidant status (TAS) and total oxidant status (TOS) were measured in serum samples of HD patients. Results: We showed for the first time that miR-21-5p expressions were increased in patients receiving HD. In addition, miR-21-5p expressions showed a significantly positive correlation with bone metabolism markers, i.e. RANKL, osteocalcin, phosphorus, and parathormone, and inflammation markers, i.e. TNF-& alpha;, IL-6, and CRP. We detected that areas under the receiver operating characteristic curve for miR-21-5p, RANKL, osteocalcin, TNF-a, IL-6, and oxidative stress index in HD patients were 0.9317, 0.7742, 0.9038, 0.7319, 0.7063, and 0.7738, respectively. Conclusion: Elevated miR-21-5p expressions are associated with routine biochemical and inflammatory markers in HD patients, suggesting that miR-21-5p might have diagnostic and/or therapeutic importance in the treatment of chronic kidney diseases.en_US
dc.description.sponsorshipScientific Research Project Fund of Hatay Mustafa Kemal University [19]en_US
dc.description.sponsorshipThis work is supported by the Scientific Research Project Fund of Hatay Mustafa Kemal University under project number 19.M.046.en_US
dc.identifier.doi10.1016/j.genrep.2023.101780
dc.identifier.issn2452-0144
dc.identifier.scopus2-s2.0-85156148126en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1016/j.genrep.2023.101780
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8828
dc.identifier.volume31en_US
dc.identifier.wosWOS:001041808100001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofGene Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChronic kidney diseaseen_US
dc.subjectHemodialysisen_US
dc.subjectmiR-21-5pen_US
dc.subjectMineral bone disordersen_US
dc.subjectInflammationen_US
dc.subjectOxidative stressen_US
dc.titleAssociation of miR-21-5p with routine biochemical markers and inflammatory cytokines in hemodialysis patientsen_US
dc.typeArticleen_US

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