Antioxidative and Anti-inflammatory Effect of Thymoquinone in an Acute Pseudomonas Prostatitis Rat Model

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dc.authoridKaplan Sefil, Nebihat/0000-0003-0091-8471
dc.authorid, ahmet/0000-0001-6274-5700
dc.authoridYonden, Zafer/0000-0003-0708-5417
dc.contributor.authorRifaioglu, Murat Mehmet
dc.contributor.authorNacar, Ahmet
dc.contributor.authorYuksel, Rana
dc.contributor.authorYonden, Zafer
dc.contributor.authorKarcioglu, Murat
dc.contributor.authorZorba, O. Unal
dc.contributor.authorDavarci, Isil
dc.date.accessioned2024-09-18T20:55:31Z
dc.date.available2024-09-18T20:55:31Z
dc.date.issued2013
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIntroduction: The aim of this study is to investigate the potential antioxidant and anti-inflammatory effects of thymoquinone (TQ) to improve acute bacterial prostatitis (ABP) induced by Pseudomonas aeruginosa. Material and Methods: A total of 42 male Wistar albino rats were divided into 7 groups as follows: control, ABP (24, 48, and 72 h), and TQ-ABP (24, 48, and 72 h). The prostate tissue samples were assayed for prostate tissue malondialdehyde (MDA) and nitric oxide (NO) levels, and catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPX) activities. Sections were examined for characteristic histological changes, and a histological scoring system was used. Results: When the ABP groups given TQ (24, 48, and 72 h) were compared to the ABP groups not given TQ, the levels of MDA and NO and the GPX activity were found to be significantly lower in the groups given TQ. Concerning SOD values, the TQ-ABP-72 group was lower in comparison with the ABP-72 and control groups, but statistically higher than the TQ-ABP-48 group (p < 0.05). Concerning CAT activity, only the TQ-ABP-72 and ABP-72 groups had a significant difference with the control group. TQ improved prostate histology significantly only in the TQ-ABP-24 group compared to the ABP-24 group (p < 0.001). Conclusion: Our study demonstrated for the first time that ABP induced by P. aeruginosa had an oxidative effect on prostate tissue and could regress following TQ administration as shown with the biochemical and histological findings. Copyright (C) 2013 S. Karger AG, Baselen_US
dc.identifier.doi10.1159/000351261
dc.identifier.endpage481en_US
dc.identifier.issn0042-1138
dc.identifier.issn1423-0399
dc.identifier.issue4en_US
dc.identifier.pmid24008979en_US
dc.identifier.scopus2-s2.0-84890056169en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage474en_US
dc.identifier.urihttps://doi.org/10.1159/000351261
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11894
dc.identifier.volume91en_US
dc.identifier.wosWOS:000327925400016en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofUrologia Internationalisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPseudomonas aeruginosaen_US
dc.subjectThymoquinoneen_US
dc.subjectAcute bacterial prostatitisen_US
dc.subjectRaten_US
dc.titleAntioxidative and Anti-inflammatory Effect of Thymoquinone in an Acute Pseudomonas Prostatitis Rat Modelen_US
dc.typeArticleen_US

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