Thr21Met (T21M) but not Ser89Asn (S89N) polymorphisms of the urotensin-II (UTS-II) gene are associated with Behcet's disease (BD)

Basit Öğe Kaydı
dc.authoridCEVIK, MUHAMMER OZGUR/0000-0002-0963-7097
dc.authoridIgci, Yusuf Ziya/0000-0001-9187-3728
dc.contributor.authorOztuzcu, Serdar
dc.contributor.authorUlasli, Mustafa
dc.contributor.authorPehlivan, Yavuz
dc.contributor.authorCevik, Muhammer Ozgur
dc.contributor.authorCengiz, Beyhan
dc.contributor.authorGogebakan, Bulent
dc.contributor.authorIgci, Yusuf Ziya
dc.date.accessioned2024-09-18T21:00:30Z
dc.date.available2024-09-18T21:00:30Z
dc.date.issued2013
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBehcet's disease (BD) is multisytemic vasculitis or chronic inflammation that may lead to various autoimmune and autoinflammatory syndromes. Exact etiopathogenesis of BD has not been clarified yet. Urotensin II (UTS-II) is predominantly a vasoactive peptide and Thr21Met polymorphism in UTS-II gene was proved to increasing in some autoimmune diseases. Considering these, our objective was to evaluate whether two UTS-II gene polymorphisms (Thr21Met and Ser89Asn) were responsible in genetic susceptibility to BD in a Turkish population. A total of 198 patients with BD and 275 healthy controls were enrolled. We analyzed the genotype and allele frequencies of two UTS-II gene polymorphisms, Thr21Met and Ser89Asn, in BD patients and in controls. We found that Thr21Met but not Ser89Asn polymorphisms of the UTS-II gene were markedly associated with the risk of developing BD (p<0.0001), The Met21Met genotype was less common among BD patients (6.1% in patients vs. 17.1% in controls; p<0.0001). There was also an increase in the 21Thr allele (54.8% in BD patients vs. 43.8% in controls) and a decrease in 21Met allele frequencies (45.2% in controls vs. 56.2% in patients) in the BD groups (p<0.0044). To the best of our knowledge, for the first time in the literature, our study claims that there is an association between Thr21Met, and not between Ser89Asn polymorphisms in the UTS-II gene and BD. These results put a new player to the field of undiscovered pathogenesis of BD and hopefully provide new insights to the treatment options. Crown Copyright (C) 2012 Published by Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.peptides.2012.12.013
dc.identifier.endpage100en_US
dc.identifier.issn0196-9781
dc.identifier.issn1873-5169
dc.identifier.pmid23333481en_US
dc.identifier.scopus2-s2.0-84874547133en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage97en_US
dc.identifier.urihttps://doi.org/10.1016/j.peptides.2012.12.013
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12727
dc.identifier.volume42en_US
dc.identifier.wosWOS:000320492800014en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofPeptidesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectUrotensin-II geneen_US
dc.subjectPolymorphismsen_US
dc.subjectBehcet's diseaseen_US
dc.titleThr21Met (T21M) but not Ser89Asn (S89N) polymorphisms of the urotensin-II (UTS-II) gene are associated with Behcet's disease (BD)en_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ N/A ]
İsim:
Tam Metin / Full Text
Boyut:
166.8 KB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu