Increased Systemic Immune-Inflammation Index Levels in Patients with Dry Eye Disease

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dc.contributor.authorOzcan, Deniz Ozarslan
dc.contributor.authorKurtul, Bengi Ece
dc.contributor.authorOzcan, Sait Coskun
dc.contributor.authorElbeyli, Ahmet
dc.date.accessioned2024-09-18T20:59:14Z
dc.date.available2024-09-18T20:59:14Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPurpose To evaluate the systemic immune-inflammation index (SII) levels, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) in patients with dry eye disease (DED) and to compare with control subjects. Methods This prospective study included 47 DED patients and 47 age- and sex-matched healthy controls. Ophthalmological examination, diagnostic DED tests, and routine complete blood cell count parameters were analyzed. The SII value was calculated as follows: platelet count x (neutrophil/lymphocyte). Results The mean SII, NLR, and PLR levels were significantly higher in DED patients compared to controls (p< .001,pp= .009, respectively). Using the receiver operating characteristics (ROC) curve analysis to predict patients with DED, the highest area under the curve (AUC) was determined SII (0.761 for SII, 0.727 for NLR, and 0.653 for PLR). Conclusions As a novel tool superior to other inflammatory markers, SII may be a cheap and reliable indicator of inflammatory status in DED patients.en_US
dc.identifier.doi10.1080/09273948.2020.1821899
dc.identifier.endpage592en_US
dc.identifier.issn0927-3948
dc.identifier.issn1744-5078
dc.identifier.issue3en_US
dc.identifier.pmid32990489en_US
dc.identifier.scopus2-s2.0-85091763802en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage588en_US
dc.identifier.urihttps://doi.org/10.1080/09273948.2020.1821899
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12474
dc.identifier.volume30en_US
dc.identifier.wosWOS:000573667300001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofOcular Immunology and Inflammationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSystemic immune-inflammation indexen_US
dc.subjectdry eye diseaseen_US
dc.subjectinflammationen_US
dc.subjectneutrophil-to-lymphocyte ratioen_US
dc.subjectplatelet-to-lymphocyte ratioen_US
dc.titleIncreased Systemic Immune-Inflammation Index Levels in Patients with Dry Eye Diseaseen_US
dc.typeArticleen_US

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