Antiepileptic effects of ghrelin on pentylenetetrazole-induced seizures in rats

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dc.contributor.authorObay, Basra Deniz
dc.contributor.authorTasdemir, Ezel
dc.contributor.authorTumer, Cemil
dc.contributor.authorBilgin, Hakki Murat
dc.contributor.authorSermet, Abdurrahman
dc.date.accessioned2024-09-18T20:19:48Z
dc.date.available2024-09-18T20:19:48Z
dc.date.issued2007
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIt is well known that neuropeptide Y (NPY) and gamma-aminobutyric acid (GABA) exert antiepileptic effects in animal models. It has recently been shown that ghrelin neurons increase the activities of GABA and NPY in the brain. Therefore it can be said that ghrelin is an antiepileptic agent. In this study we aimed to investigate the antiepileptic effect of ghrelin in an acute experimental epilepsy model in pentylenetetrazole (PTZ) injected rats. Adult male Wistar albino rats were divided into a control group and four experimental groups with seven rats in each group. In order to generate epileptic seizures, PTZ (50 mg/kg) was injected intraperitone ally. The experimental groups received intraperitoneal injections of ghrelin at doses of 20,40, 60 and 80 mu g/kg 30 min before PTZ injection. After PTZ injection, the latencies were separated into three components: first myoclonic jerk, generalized clonic seizures and tonic generalized extension. The injection of 50 mg/kg PTZ-induced epileptic seizures in the control group. The onset-times of the three characteristic behavioral changes were significantly delayed and the duration of tonic generalized extension was diminished by dose-dependent ghrelin administration. Our results demonstrated that ghrelin suppresses the onset time of PTZ-induced seizures. In the light of our current knowledge, it seems that ghrelin may be considered as an antiepileptic drug. (c) 2007 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.peptides.2007.04.003
dc.identifier.endpage1219en_US
dc.identifier.issn0196-9781
dc.identifier.issn1873-5169
dc.identifier.issue6en_US
dc.identifier.pmid17512090en_US
dc.identifier.scopus2-s2.0-34249694588en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1214en_US
dc.identifier.urihttps://doi.org/10.1016/j.peptides.2007.04.003
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9856
dc.identifier.volume28en_US
dc.identifier.wosWOS:000247701500009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofPeptidesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectepilepsyen_US
dc.subjectghrelinen_US
dc.subjectpentylenetetrazole (PTZ)en_US
dc.titleAntiepileptic effects of ghrelin on pentylenetetrazole-induced seizures in ratsen_US
dc.typeArticleen_US

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