Activity of bisbenzimidazoles derivatives to Staphylococcus epidermidis

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dc.authorscopusid6507133577
dc.authorscopusid35612683100
dc.contributor.authorAlgul, Oztekin
dc.contributor.authorDuran, Nizami
dc.date.accessioned2024-09-19T15:43:33Z
dc.date.available2024-09-19T15:43:33Z
dc.date.issued2007
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBiomaterial-associated infections, most frequently caused by Staphylococcus epidermidis and Staphylococcus aureus, are of increasing importance in modern medicine. The most important factor in the pathogenesis of biomaterial- associated staphylococcal infections is the formation of adherent, multilayered bacterial biofilms. The aim of this study was to synthesize bis(benzimidazole) derivatives and evaluate their in vitro antimicrobial activity against the growth of gram positive (Enterococcus faecalis, methicillin resistant S. aureus, methicillin sensitive S.aureus, S. epidermidis and S. epidermidis RP12 (slime producing), gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa) and pathogenic fungi (Candida albicans, Candida krusei, Candida parapsilosis, Candida tropicalis and Candida glabrata). The antimicrobial activity of bis(benzimidazole) derivatives was higher in gram positive bacteria. Bis(benzimidazole) derivatives were inhibited gram positive bacteria at the concentration range of 12.5-100 ?g/mL. All compounds were shown to be bacteriostatic as well as bacteriocidal for cultures of S. aureus and S. epidermidis strains, regardless of their antibiotic susceptibility profile. This was demonstrated by using simultaneously the optical density measuring method and 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide-reduction assay. The highest activity was shown by 1,2-di(1H-benzo[d]imidazol-2-yl)ethane which demonstrated interesting activity regarding its effect on 24 h old staphylococcal biofilm cells viability.en_US
dc.identifier.endpage3151en_US
dc.identifier.issn0970-7077
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-37049025966en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage3145en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14407
dc.identifier.volume19en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherChemical Publishing Co.en_US
dc.relation.ispartofAsian Journal of Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntimicrobial activityen_US
dc.subjectBiofilmen_US
dc.subjectBis(benzimidazole)en_US
dc.subjectStaphylococcus epidermidisen_US
dc.titleActivity of bisbenzimidazoles derivatives to Staphylococcus epidermidisen_US
dc.typeArticleen_US

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