Androgen status of the nonautoimmune dry eye subtypes

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dc.contributor.authorTamera, Cengaver
dc.contributor.authorOksuz, Huseyin
dc.contributor.authorSogut, Sadik
dc.date.accessioned2024-09-18T20:52:46Z
dc.date.available2024-09-18T20:52:46Z
dc.date.issued2006
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPurpose: To evaluate androgen levels of patients diagnosed with nonautoimmune dry eye, either with meibomian gland dysfunction (MGD) or without MGD (non-MGD), and normal control subjects. This is a prospective, comparative, case-control study. Methods: Sixty-four (32 men and 32 women) subjects were enrolled for each of the three diagnostic groups. All dry eye patients were symptom positive. Non-fasting testosterone (T), sex hormone-binding globulin, serum albumin, dehydroepiandrosterone (DHEA), and DHEA sulphate levels of all study participants were determined using either automated immunoenzymatic assay, or standard radioimmunoassay. Analysis of variance was used to compare androgen levels among the three diagnostic groups in a gender-based design, followed by post-hoc multiple comparisons with the Tukey honestly significant difference test. Results: Mean T levels in men and women of the three diagnostic groups were not significantly different (p = 0.808, p = 0.156, respectively; ANOVA). Statistical analyses of the three diagnostic groups revealed a significant difference for men and women in bioavailable T levels (p = 0.002, p = 0.014, respectively; ANOVA), DHEA levels (p = 0.009, p = 0.004, respectively; ANOVA), and DHEA sulphate levels (p = 0.001, p = 0.001, respectively; ANOVA), whereas there was no statistically significant difference between non-MGD dry eye patients and controls for any of the measured androgen levels according to the post-hoc tests. Conclusion: This study demonstrates that the androgen pool of nonautoimmune dry eye patients with MGD is significantly depleted compared with that of non-MGD and control cases. Copyright (c) 2006 S. Karger AG, Basel.en_US
dc.identifier.doi10.1159/000095771
dc.identifier.endpage286en_US
dc.identifier.issn0030-3747
dc.identifier.issue5en_US
dc.identifier.pmid16974129en_US
dc.identifier.scopus2-s2.0-33749355587en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage280en_US
dc.identifier.urihttps://doi.org/10.1159/000095771
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11383
dc.identifier.volume38en_US
dc.identifier.wosWOS:000241156300008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofOphthalmic Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectnonautoimmune dry eyeen_US
dc.subjecttestosteroneen_US
dc.subjectbioavailable testosteroneen_US
dc.subjectdehydroxyepiandrosteroneen_US
dc.subjectdehydroxyepiandrosterone sulphateen_US
dc.titleAndrogen status of the nonautoimmune dry eye subtypesen_US
dc.typeArticleen_US

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