Changes in Selected Immunological Parameters and Oxidative Stress Responses in Different Organs of Oncorhynchus mykiss Exposed to Ivermectin

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dc.authoridYonar, M. Enis/0000-0001-9519-4247
dc.authoridSaglam, Naim/0000-0002-3163-8432
dc.contributor.authorSakin, Fatih
dc.contributor.authorYonar, Serpil Mise
dc.contributor.authorYonar, M. Enis
dc.contributor.authorSaglam, Naim
dc.date.accessioned2024-09-18T20:55:38Z
dc.date.available2024-09-18T20:55:38Z
dc.date.issued2012
dc.departmentHatay Mustafa Kemal Ãœniversitesien_US
dc.description.abstractIn this study, effects of ivermectin on selected immunological parameters, oxidative stress, and antioxidant status in the blood, liver, kidney, heart, and spleen of the rainbow trout (Oncorhynchus mykiss) were examined. Ivermectin was administered intraperitoneally at single doses of 0.01 and 0.02 mg ivermectin kg(-1) fish. Blood and tissue samples (liver, kidney, heart, and spleen) were then removed on days 3, 7, 10, and 14 for immunological and biochemical analyses. The immunological parameters measured were numbers of leucocytes (WBC), nitroblue tetrazolium activity (NBT), total plasma protein (TP), and total immunoglobulin (TI). Malondialdehyde (MDA) values were measured in the liver, kidney, heart, and spleen tissues as indexes of oxidation, and the activities of catalase (CAT), reduced glutathione (GSH), glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD) were measured as indexes of antioxidant status. The results showed a decrease in the WBC value, NBT activity, and TP and TI levels after the injection of 0.01 and 0.02 mg ivermectin kg(-1) fish (p <0.05, 0.01, 0.001). Our results suggest that ivermectin at these doses causes oxidation in fish liver, kidney, heart, and spleen tissues due to impairment of the antioxidant system.en_US
dc.identifier.endpage995en_US
dc.identifier.issn0034-7752
dc.identifier.issue10en_US
dc.identifier.startpage989en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11968
dc.identifier.volume63en_US
dc.identifier.wosWOS:000311927200004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherRevista Chimie Srlen_US
dc.relation.ispartofRevista De Chimieen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRainbow trouten_US
dc.subjectivermectinen_US
dc.subjectimmunological parameteren_US
dc.subjectantioxidant statusen_US
dc.subjectoxidative stressen_US
dc.subjectpesticideen_US
dc.subjectantiparasitic drugen_US
dc.titleChanges in Selected Immunological Parameters and Oxidative Stress Responses in Different Organs of Oncorhynchus mykiss Exposed to Ivermectinen_US
dc.typeArticleen_US

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