Protective effect of lycopene on oxidative stress induced by different doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin in brain, liver, kidney, and heart tissue of rats

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dc.authorscopusid14037995800
dc.authorscopusid44961187200
dc.authorscopusid6507928515
dc.authorscopusid7006538915
dc.contributor.authorSakin, Fatih
dc.contributor.authorBulmuş, Funda Gülcü
dc.contributor.authorServi, Kadir
dc.contributor.authorPopa, Lacramioara
dc.date.accessioned2024-09-19T15:47:03Z
dc.date.available2024-09-19T15:47:03Z
dc.date.issued2011
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the possible protective role of lycopene (LYC) on liver, kidney, heart, and brain in male rats exposed to different doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Forty-eight rats were divided into six groups. The first group received 0.5 mL corn oil as control; the second group was treated with 10 mg/kg bw/day LYC. Groups 3 and 4 were treated to 50 and 500 ng/kg bw/day of TCDD, respectively. Groups 5 and 6 were subjected to 50 and 500 ng/kg bw/day of TCDD along with 10 mg/kg bw/day of LYC, simultaneously. The duration of the experiment was 13 weeks. While the exposure to TCDD increased the levels of malondialdehyde (MDA), it decreased glutathione (GSH) levels, and superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) activities. However, LYC-treatment decreased the high MDA levels and increased GSH, SOD, GSH-Px, and CAT activities. In conclusion, LYC treatment decreased TCDD-induced lipid peroxidation and supported the antioxidant activity. It is suggested that LYC has a protective effect against oxidative stress induced by TCDD.en_US
dc.identifier.endpage470en_US
dc.identifier.issn0014-8237
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-79960960187en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage462en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14940
dc.identifier.volume59en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofFarmaciaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDioxinen_US
dc.subjectLycopeneen_US
dc.subjectOxidative stressen_US
dc.subjectToxicityen_US
dc.titleProtective effect of lycopene on oxidative stress induced by different doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin in brain, liver, kidney, and heart tissue of ratsen_US
dc.typeArticleen_US

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