Smoking and sickle cell diseases

Basit Öğe Kaydı
dc.authorscopusid12796585800
dc.authorscopusid7005479833
dc.authorscopusid35966236600
dc.authorscopusid20134706500
dc.contributor.authorHelvaci, Mehmet Rami
dc.contributor.authorSevinc, Alper
dc.contributor.authorCamci, Celaletdin
dc.contributor.authorKeskin, Ali
dc.date.accessioned2024-09-19T15:43:40Z
dc.date.available2024-09-19T15:43:40Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: We tried to understand whether or not there is an association between higher prevalence of smoking and autosplenectomy in sickle cell diseases (SCDs) cases. Methods: All SCDs patients with and without autosplenectomy were studied, and they were compared in between. Results: The study included 253 patients (124 females). There were 168 cases (66.4%) with autosplenectomy and 85 cases (33.5%) without (p<0.001). Autosplenectomy cases were significantly elder than the others (30.7 versus 25.7 years, p= 0.000). Female ratios were similar in both groups (p>0.05). Thalassemia minors were significantly higher in cases without autosplenectomy (91.7% versus 50.0%, p<0.001). Interestingly, prevalence of smoking was significantly higher in cases with autosplenectomy (16.6% versus 9.4%, p<0.05). The mean units of transfused red blood cells (RBCs) and painful crises per year were similar in both groups (p>0.05 for both). Both the white blood cell and platelet counts of the peripheric blood were higher in cases with autosplenectomy, significantly (p = 0.000 for both), whereas the mean hematocrit value was significantly lower in them (p= 0.000). On the other hand, prevalences of digital clubbing, pulmonary hypertension, leg ulcers, chronic renal disease, coronary heart disease, and rheumatic heart disease were significantly higher in cases with autosplenectomy (p<0.05 for all). Conclusion: Due to the strong atherosclerotic background of smoking and SCDs, there may be an association between higher prevalence of smoking and clinical severity of the SCDs, and the spleen, as a filter of blood for the abnormally hard RBCs, may strongly be affected in smoker patients with SCDs.en_US
dc.identifier.endpage3722en_US
dc.identifier.issn1205-6626
dc.identifier.issue8en_US
dc.identifier.scopus2-s2.0-84906751275en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage3706en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14493
dc.identifier.volume20en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherCardiology Academic Pressen_US
dc.relation.ispartofExperimental and Clinical Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAtherosclerosisen_US
dc.subjectAutosplenectomyen_US
dc.subjectSickle cell diseasesen_US
dc.subjectSmokingen_US
dc.titleSmoking and sickle cell diseasesen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu