Comparison of efficacy of Tc-99m HIG and Tc-99m nanocolloid on sentinel lymph node mapping in patients with breast cancer

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dc.authoridOzen, Aynur/0000-0002-0648-8831
dc.authoridAktas, Ayse/0000-0003-0149-2265
dc.authoridGENCOGLU, ESRA ARZU/0000-0003-4631-1683
dc.contributor.authorYalcin, Hulya
dc.contributor.authorGencoglu, Esra Arzu
dc.contributor.authorYagmurdur, Mahmut
dc.contributor.authorAras, Murat
dc.contributor.authorOzen, Aynur
dc.contributor.authorAktas, Ayse
dc.date.accessioned2024-09-18T20:16:37Z
dc.date.available2024-09-18T20:16:37Z
dc.date.issued2010
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground and aim This study compared the effectiveness of Tc-99m human polyclonal immunoglobulin (HIG) and Tc-99m nanocolloid at detecting sentinel lymph nodes (SLNs) with lymphoscintigraphy and an intraoperative gamma-probe (IGP) in patients with early breast cancer. Methods The study group consisted of 50 women; 25 patients each were given Tc-99m HIG or Tc-99m nanocolloid for lymphoscintigraphy. Then, intraoperative SLN localization with IGP was performed. The results of IGP, lymphoscintigraphy, blue dye injected just before surgery, and pathology were compared. Results In the Tc-99m HIG group, one patient had tumours in both breasts. In two patients, we could not detect SLNs with lymphoscintigraphy, although they were detected with IGP and blue dye. We found SLNs for all tumours with IGP. With the intraoperative blue dye, SLNs were identified for 25 tumours; for one tumour, no SLN was detected with blue dye. In the histopathological examination, 13 tumours showed metastasis in the SLN and in 11 of these 13, there were also metastases in the axilla. One patient had a skip metastasis. In the Tc-99m nanocolloid group, SLNs were identified in 24 patients with lymphoscintigraphy. IGP found SLNs in 24 patients. The blue dye detected SLNs in all patients. On histopathological examination, 10 patients had metastasis in the SLN and there were also metastases in the axilla in all of these patients. Conclusion Tc-99m HIG can be used in SLN detection with preoperative lymphoscintigraphy and IGP in early-stage breast cancer patients. Nucl Med Commun 31:903-909 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.en_US
dc.identifier.doi10.1097/MNM.0b013e32833dedbf
dc.identifier.endpage909en_US
dc.identifier.issn0143-3636
dc.identifier.issn1473-5628
dc.identifier.issue10en_US
dc.identifier.pmid20683362en_US
dc.identifier.scopus2-s2.0-77957348872en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage903en_US
dc.identifier.urihttps://doi.org/10.1097/MNM.0b013e32833dedbf
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9634
dc.identifier.volume31en_US
dc.identifier.wosWOS:000281925200010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofNuclear Medicine Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectearly-stage breast canceren_US
dc.subjectintraoperative gamma-probeen_US
dc.subjectlymphoscintigraphyen_US
dc.subjectTc-99m HIGen_US
dc.subjectTc-99m nanocolloiden_US
dc.titleComparison of efficacy of Tc-99m HIG and Tc-99m nanocolloid on sentinel lymph node mapping in patients with breast canceren_US
dc.typeArticleen_US

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