Ellagic acid prevents kidney injury and oxidative damage via regulation of Nrf-2/NF-?B signaling in carbon tetrachloride induced rats

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dc.authoridBeyaz, Seda/0000-0003-0436-8112
dc.authoridAslan, Abdullah/0000-0002-6243-4221
dc.authoridGOK, OZLEM/0000-0001-8521-6369
dc.contributor.authorAslan, Abdullah
dc.contributor.authorGok, Ozlem
dc.contributor.authorBeyaz, Seda
dc.contributor.authorAgca, Can Ali
dc.contributor.authorErman, Orhan
dc.contributor.authorZerek, Aykut
dc.date.accessioned2024-09-18T20:06:31Z
dc.date.available2024-09-18T20:06:31Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPhytochemicals, bioactive food compounds, found in plants have been described as protective agents against renal injury. This work was planned to evaluate the effects of EA on anti-oxidative and anti-inflammation pathways in kidney damage induced with carbon tetrachloride. In this study, experimental animals (n = 36, 8 weeks old rats) were divided into 4 groups as follows: 1) Control group 2) EA group (10 mg/kg body weight) 3) CCl4 group (1.5 ml/kg, body weight) 4) EA + CCl4 group. The potentially protective effect of EA on kidney damage exposed by CCl4 in rats were evaluated. EA administration protects CCl4 induced kidney damage against oxidative stress through its antioxidant protection. Treatment of EA significantly reduced lipid peroxidation and improved glutathione and catalase enzyme activity. Recently studies showed that EA activated caspase-3 and nuclear transcription factor erythroid 2 related factor driven antioxidant signal pathway and protected the kidney against damage induced by oxidative stress. Furthermore, EA also markedly decreased the level of cyclooxygenase-2, the vascular endothelial growth factor and tumor necrosis factor-alpha and suppressed the protein synthesis of nuclear factor-kappa-B. This study reveals that EA has kidney protective effect against CCl4 induced oxidative damage and inflammation. [GRAPHICS] .en_US
dc.description.sponsorshipFirat University Scientific Research Projects Unit (FUBAP) [FF.16.42]en_US
dc.description.sponsorshipThe article supported by Firat University Scientific Research Projects Unit (FUBAP) with FF.16.42 project number. In addition, some of the results of this article were presented at the 20th International Biotechnology Congress with International Participation, 10-12 October 2019, Baskent University-Ankara.en_US
dc.identifier.doi10.1007/s11033-020-05873-x
dc.identifier.endpage7970en_US
dc.identifier.issn0301-4851
dc.identifier.issn1573-4978
dc.identifier.issue10en_US
dc.identifier.pmid33006714en_US
dc.identifier.scopus2-s2.0-85091878464en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage7959en_US
dc.identifier.urihttps://doi.org/10.1007/s11033-020-05873-x
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8559
dc.identifier.volume47en_US
dc.identifier.wosWOS:000574722700004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofMolecular Biology Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCarbon tetrachlorideen_US
dc.subjectCOX-2en_US
dc.subjectEllagic aciden_US
dc.subjectKidneyen_US
dc.subjectNF-kappa Ben_US
dc.subjectNrf-2en_US
dc.subjectVEGFen_US
dc.titleEllagic acid prevents kidney injury and oxidative damage via regulation of Nrf-2/NF-?B signaling in carbon tetrachloride induced ratsen_US
dc.typeArticleen_US

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