Calcium Fructoborate Prevents Skin Cancer Development in Balb-c Mice: Next Part, Reverse Inflammation, and Metabolic Alteration

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dc.authoridYaman, Mehmet/0000-0002-3008-2671
dc.authoridKISACAM, Mehmet Ali/0000-0003-0521-9434
dc.contributor.authorKisacam, Mehmet Ali
dc.contributor.authorKocamuftuoglu, Gonca Ozan
dc.contributor.authorOzan, Ibrahim Enver
dc.contributor.authorYaman, Mehmet
dc.contributor.authorOzan, SemaTemizer
dc.date.accessioned2024-09-18T20:06:22Z
dc.date.available2024-09-18T20:06:22Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractMetabolic alterations and inflammation are regarded as hallmarks of cancer. Glycolytic flux and intermediate accumulation lead to the production of building blocks and NADPH which is important in protecting the cell from oxidative damage. Inflammation causes the release of mediators responsible for regulating molecular mechanism affecting metabolic pathways. CaFB due to its cis-diol-rich feature may have the potential to interact with molecules taking part in cancer development. This study was aimed to investigate the effects of CaFB on metabolic alterations and inflammation in 7,12-dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin cancer. For this purpose, 92 Balb-c mice were distributed into 6 groups as control, CaFB, DMBA/TPA (D-T), treatment 1 (T1), 2 (T2), and 3(T3). Apart from control and CaFB in other groups, tumors initiated with 97.5-nmol DMBA and 6.5-nmol TPA. Treatment groups received 3 mg/kg/day CaFB with DMBA (T1), with TPA (T2), and after tumor formation (T3). In the D-T group, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) activity, 6-phosphogluconate dehydrogenase (PGD), glutathione (GSH), interleukin 6 (IL-6), (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha) levels increased (p < 0.001) while malondialdehyde (MDA) levels decreased (p < 0.001) compared with that in control. CaFB application ameliorated DMBA-TPA effect according to the distribution time. It is noteworthy to consider CaFB as a potential preventive agent in skin cancer development.en_US
dc.description.sponsorshipNational Boron Institution of Turkey [2016-31-07-15-003]en_US
dc.description.sponsorshipThis project was funded by the National Boron Institution of Turkey grant number: 2016-31-07-15-003.en_US
dc.identifier.doi10.1007/s12011-020-02363-w
dc.identifier.endpage2634en_US
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue7en_US
dc.identifier.pmid32880800en_US
dc.identifier.scopus2-s2.0-85090191309en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2627en_US
dc.identifier.urihttps://doi.org/10.1007/s12011-020-02363-w
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8488
dc.identifier.volume199en_US
dc.identifier.wosWOS:000566461700002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringernatureen_US
dc.relation.ispartofBiological Trace Element Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCalcium fructoborateen_US
dc.subjectSkin canceren_US
dc.subjectGlyceraldehyde-3-phosphate dehydrogenaseen_US
dc.subject6-Phosphogluconate dehydrogenaseen_US
dc.subjectInflammationen_US
dc.subjectOxidative stressen_US
dc.titleCalcium Fructoborate Prevents Skin Cancer Development in Balb-c Mice: Next Part, Reverse Inflammation, and Metabolic Alterationen_US
dc.typeArticleen_US

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