Antiperoxidative and anti-apoptotic effects of lycopene and ellagic acid on cyclophosphamide-induced testicular lipid peroxidation and apoptosis

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dc.authoridTurk, Gaffari/0000-0001-7417-1038
dc.authoridCeribasi, Ali Osman/0000-0002-6096-4042
dc.authoridATESSAHIN, Ahmet/0000-0002-1004-2146
dc.contributor.authorTurk, Gaffari
dc.contributor.authorCeribasi, Ali Osman
dc.contributor.authorSakin, Fatih
dc.contributor.authorSonmez, Mustafa
dc.contributor.authorAtessahin, Ahmet
dc.date.accessioned2024-09-18T20:59:04Z
dc.date.available2024-09-18T20:59:04Z
dc.date.issued2010
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe present study was conducted to investigate the possible protective effects of lycopene (LC) and ellagic acid (EA) on cyclophosphamide (CP)-induced testicular and spermatozoal toxicity associated with the oxidative stress and apoptosis in male rats. Forty-eight healthy adult male Sprague-Dawley rats were divided into six groups of eight rats each. The control group was treated with placebo; the LC, EA and CP groups were given LC (10 mg kg(-1)), EA (2 mg kg(-1)) and CP (15 mg kg(-1)), respectively, alone; the CP+LC group was treated with a combination of CP (15 mg kg(-1)) and LC (10 mg kg(-1)); and the CP+EA group was treated with a combination of CP (15 mg kg(-1)) and EA (2 mg kg(-1)). All treatments were maintained for 8 weeks. At the end of the treatment period, bodyweight and the weight of the reproductive organs, sperm concentration and motility, testicular tissue lipid peroxidation, anti-oxidant enzyme activity and apoptosis (i.e. Bax and Bcl-2 proteins) were determined. Administration of CP resulted in significant decreases in epididymal sperm concentration and motility and significant increases in malondialdehyde levels. Although CP significantly increased the number of Bax-positive (apoptotic) cells, it had no effect on the number of Bcl-2-positive (anti-apoptotic) cells compared with the control group. However, combined treatment of rats with LC or EA in addition to CP prevented the development of CP-induced lipid peroxidation and sperm and testicular damage. In conclusion, CP-induced lipid peroxidation leads to structural and functional damage, as well as apoptosis, in spermatogenic cells of rats. Both LC and EA protect against the development of these detrimental effects.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [106O123]en_US
dc.description.sponsorshipThe authors acknowledge the financial support of The Scientific and Technological Research Council of Turkey (TUBITAK; project no. 106O123. In addition, the authors express their gratitude to Professor Dr Mehmet Calicioglu (Department of Food Hygiene, Faculty of Veterinary Medicine, Firat University, Elazig, Turkey) for help with the English expression.en_US
dc.identifier.doi10.1071/RD09078
dc.identifier.endpage596en_US
dc.identifier.issn1031-3613
dc.identifier.issn1448-5990
dc.identifier.issue4en_US
dc.identifier.pmid20353718en_US
dc.identifier.scopus2-s2.0-77950603347en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage587en_US
dc.identifier.urihttps://doi.org/10.1071/RD09078
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12342
dc.identifier.volume22en_US
dc.identifier.wosWOS:000276106000001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCsiro Publishingen_US
dc.relation.ispartofReproduction Fertility and Developmenten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectsperm characteristicsen_US
dc.titleAntiperoxidative and anti-apoptotic effects of lycopene and ellagic acid on cyclophosphamide-induced testicular lipid peroxidation and apoptosisen_US
dc.typeArticleen_US

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