The effects of daylight exposure on melatonin levels, Kiss1 expression, and melanoma formation in mice

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dc.contributor.authorPazarci, Percin
dc.contributor.authorKaplan, Halil
dc.contributor.authorAlptekin, Davut
dc.contributor.authorYilmaz, Mehmet
dc.contributor.authorLuleyap, Umit
dc.contributor.authorSingirik, Ergin
dc.contributor.authorPelit, Aykut
dc.date.accessioned2024-09-18T21:06:38Z
dc.date.available2024-09-18T21:06:38Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAim To determine how daylight exposure in mice affects melatonin protein expression in blood and Kiss1 gene expression in the hypothalamus. The second aim was to as sess the relationship between skin cancer formation, day-light exposure, melatonin blood level, and kisspeptin gene expression level. Methods New-born mice (n = 96) were assigned into the blind group or daylight group. The blind group was raised in the dark and the daylight group was raised under 12 hours light/12 hours dark cycle for 17 weeks. At the end of the 11th week, melanoma cell line was inoculated to mice, and t timor growth was observed for 6 weeks. At the end of the experiment, melatonin level was measured from blood serum a rid Kiss1 expression from the hypothalamus. Results The blind group had significantly higher meta tonin and lower Kiss1 expression levels than the daylight group. Tumor volume was inversely proportional to melatonin levels and directly proportional to Kiss1 expression levels. Tumor growth speed was lower in the blind than in the daylight group. Conclusion Melatonin and Kiss1 were shown to be nvolved in tumor suppression. They were affected by daylight and were mutually affected by each other.en_US
dc.description.sponsorshipCukurova University Research Fund [TDK-2015-2966]en_US
dc.description.sponsorshipThis research was supported by Cukurova University Research Fund (TDK-2015-2966).en_US
dc.identifier.doi10.3325/cmj.2020.61.55
dc.identifier.endpage61en_US
dc.identifier.issn0353-9504
dc.identifier.issn1332-8166
dc.identifier.issue1en_US
dc.identifier.pmid32118379en_US
dc.identifier.scopus2-s2.0-85080840023en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage55en_US
dc.identifier.urihttps://doi.org/10.3325/cmj.2020.61.55
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13741
dc.identifier.volume61en_US
dc.identifier.wosWOS:000537838600009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMedicinska Nakladaen_US
dc.relation.ispartofCroatian Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCircadian-Rhythmen_US
dc.subjectCanceren_US
dc.subjectSleepen_US
dc.subjectMechanismsen_US
dc.titleThe effects of daylight exposure on melatonin levels, Kiss1 expression, and melanoma formation in miceen_US
dc.typeArticleen_US

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